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NAT2基因多态性与结核病患者异烟肼个体化用药剂量的选择 被引量:4

Thepolymorphism of NAT2 gene and its effects on individualized isoniaziddosage choosing for tuberculosis patients
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摘要 药物基因组学是研究基因多态性所致的相同疾病对相同药物的不同反应的科学,其以药物效应及安全性为目标,研究基因多态性与药效及安全性的关系,强调个体化、因人而异,属于精准治疗的范畴。随着医学的发展,疾病的治疗方式正逐步从统一方案、相同剂量的粗放型治疗模式转向考虑不同患者自身存在的差异的精准化治疗模式。国内外越来越多的药物基因组学相关产品已逐步上市,通过检测患者基因多态性指导患者用药种类、用药剂量的选择,多见于肿瘤治疗、抗凝药物和心血管类药物的使用。
作者 黄海荣 HUANG Hai-rong
出处 《新发传染病电子杂志》 2017年第3期143-145,150,共4页 Electronic Journal of Emerging Infectious Diseases
基金 首都卫生发展科研专项(2016-2-1041) 北京市通州区科技计划(KJ2017CX076)
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  • 1World Health Organization. Tuberculosis facts 2009 update [EB/OL]. (2009-12 09) [2010-03-18]. http://www, who. in/tb/publications/2009/factsheet_tb_2OOgupdate_dec09, pdf.
  • 2Ray J, Gardiner I, Marriott D. Managing antituberculosis drug therapy by therapeutic drug monitoring of rifampicin and isc~ niazid. Intern Med J, 2003,33 (5/6) : 229-234.
  • 3Hein DW, Doll MA, Fretland AJ, et al. Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymor- phisms. Cancer Epidemiol Biomarkers Prev, 2000,9 ( 1 ) : 29-42.
  • 4Zang Y,Doll MA, Zhao S, et al. Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2. Carcinogenesis, 2007,28(8) : 1665-1671.
  • 5Cascorbi I, Drakoulis N, Brockm/511er J, et al. Arylamine N-acetyltransferase(NAT2) mutations and their allelic linkage in unrelated Caucasian individuals:correlation with phenotypic activity. Am J Hum Genet,1995,57(3) :581-592.
  • 6Blum M, Demierre A, Grant DM, et al. Molecular mechanism of slow acetylation of drugs and carcinogens in humans. Proc Natl Acad Sci U S A,1991,88(12):5237-5241.
  • 7Delomfnie C, Sica L, Grant DM, et al. Genotyping of the polymorphic N-acetyltransferase(NAT2 * ) gene locus in two native African populations. Pharmaeogenetics, 1996, 6 (2) : 177-185.
  • 8Fukino K, Sasaki Y, Hirai S ferase 2 ( NAT2 ), CYP2E1 et al. Effect of N-acetyltrans- and Glutathione-S-transferase (GST) genotype on the serum concentrations of isoniazid and metabolites in tuberculosis patients. J Toxicol Sci, 2008, 33 (2):187 195.
  • 9Lin HJ, Han CY, Lin BK, et al. Slow acetylator mutations in the human polymorphic N-acetyltransferase gene in 786 Asians, blacks, Hispanics, and whites: application to metabolic epidemiology. Am J Hum Genet, 1993, 52(4) :827-834.
  • 10Takakubo F, Yamamoto M, Ogawa N, et al. Genetic associa- tion between cytoehrome P450IA1 gene and susceptibility to Parkinson' s disease. J Neural Transm, 1996, 103 (7): 843-849.

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