摘要
目的探讨阿哌沙班对脊柱创伤患者椎弓根螺钉术后血液流变学、炎性因子及凝血功能的影响。方法选取2014年1月—2016年12月收治的脊柱创伤98例,均行椎弓根螺钉术治疗,根据其术后应用药物的不同分为对照组46例和观察组52例,2组均予以术后常规及对症处理,对照组术后予以低分子肝素,观察组术后予以阿哌沙班。治疗结束后比较2组血液流变学、炎性因子及凝血功能相关指标水平,并记录2组治疗过程中不良反应发生情况。结果 2组治疗后血液流变学及炎性因子水平均较治疗前下降,且观察组低于对照组(P <0. 05)。2组治疗后凝血功能比较差异无统计学意义(P>0. 05)。2组均未出现明显严重不良反应。结论阿哌沙班可显著改善脊柱创伤患者椎弓根螺钉术后其血液流变学状况和降低其炎性因子水平,对凝血功能无明显影响,且具有一定的安全性。
Objective To investigate effects of Apixaban on hemorheology,inflammatory factors and coagulation function in treatment of patients with spinal trauma after pedicle screw surgery.Methods A total of 98 spinal trauma patients undergoing pedicle screw surgery during January 2014 and December 2016 were divided into control group(n=46)and observation group(n=52)according to different drugs use after surgery.All patients received postoperative symptomatic treatment,and then control group was treated with postoperative low molecular heparin,while observation group was treated with postoperative Apixaban.After operation,related indexes levels of hemorrheology,inflammatory factors,coagulation function were compared,and incidence rates of adverse reactions during the treatment were recorded in two groups.Results After treatment,levels of hemorheology and inflammatory factors were significantly lower than those before treatment in two groups,and the levels in observation group were significantly lower than those in control group(P<0.05).There was no significant difference in coagulation function between two groups after treatment(P>0.05).No serious adverse reactions were found in two groups.Conclusion Apixaban may significantly improve hemorheology condition and reduce levels of inflammatory factors in treatment of patients with spinal trauma after pedicle screw surgery with a certain safety,but it has no obvious effect on coagulation function.
作者
周宇
刘跃洪
刘树平
陈曦
覃伟
ZHOU Yu;LIU Yue-hong;LIU Shu-ping;CHEN Xi;TAN Wei(Department of Orthopedics,Deyang People's Hospital,Deyang,Sichuan 618000,China)
出处
《解放军医药杂志》
CAS
2019年第1期67-70,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
四川省卫生厅课题(17PJ213
17PJ408
17ZD023)
关键词
脊柱创伤
阿哌沙班
血液流变学
炎性因子
凝血功能
Spinal trauma
Apixaban
Hemorheology
Inflammatory factor
Coagulation function
