摘要
目的:探讨复方中药强骨饮对骨质疏松性椎体压缩性骨折(OVCF)患者愈合程度及骨代谢指标的影响。方法:选取2013年6月至2016年6月广东省汕头市中医医院收治的OVCF患者100例,依据治疗方法分为观察组和对照组,每组50例,所有患者均行经皮椎体成形术(PVP)治疗,对照组给予碳酸钙D3片治疗,观察组在对照组基础上给予复方中药强骨饮治疗。结果:观察组和对照组治疗后血清碱性磷酸酶(ALP)、尿脱氧吡啶酚(DPD)水平和疼痛视觉模拟评分法(VAS)评分明显低于治疗前(P <0. 05),观察组治疗后血清ALP、DPD水平和VAS评分明显低于对照组(P <0. 05);观察组和对照组治疗后腰椎L1～L4、大粗隆骨密度和Cobb角、椎体前缘高度明显高于治疗前(P <0. 05),观察组治疗后腰椎L1～L4、大粗隆骨密度和Cobb角、椎体前缘高度明显高于对照组(P <0. 05);随访12个月期间,观察组再发椎体骨折率明显低于对照组,差异有统计学意义(P <0. 05)。结论:复方中药强骨饮治疗可有效改善OVCF患者骨代谢及骨密度,有利于减轻患者疼痛感及促进患者骨折愈合,且可有效降低再发椎体骨折的风险,值得临床进一步推广。
Objective:To discuss the effects of Compound Qianggu Decoction on the healing degree and bone metabolism of patients with osteoporotic vertebral compressibility fracture (OVCF).Methods:A total of 100 patients with OVCF were selected from June 2013 and June 2016 in Shantou Hospital of Traditional Chinese Medicine.According to the treatment,all patients were divided into Compound Qianggu Decoction group (50 cases) and control group (50 cases).All patients were treated with percutaneous vertebroplasty (PVP),and control group was given calcium carbonate D3 tablets,on the basis of which Compound Qianggu Decoction group was given Compound Qianggu Decoction.Results:Serum alkaline phosphatase (ALP),urinary deoxypyridine (DPD) level and pain visual analogue scoring (VAS) scores in the Compound Qianggu Decoction group and control group were significantly decreased after treatment,and those of Compound Qianggu Decoction group after treatment were significantly lower than those of the control group.The density of lumbar L1-4,large tuberosity and height of Cobb Angle and vertebral anterior border were significantly increased after treatment,and those of Compound Qianggu Decoction group were statistically significantly higher than those of the control group (P<0.05).During the 12-month follow-up period,the recurrence rate of bone fracture of redistributed vertebral body in Compound Qianggu Decoction group was significantly lower than that in the control group,and the difference was statistically significant (P<0.05).Conclusion:The treatment of Compound Qianggu Decoction can effectively improve bone metabolism and bone density in OVCF patients,and it is helpful to alleviate pain and promote healing of fracture,and it can reduce the risk of vertebral fracture effectively,which is worthy of further clinical promotion.
作者
吴东生
苏先喆
Wu Dongsheng;Su Xianzhe(First Orthopedics Department,Shantou Hospital of Traditional Chinese Medicine,Shantou 515031,China)
出处
《世界中医药》
CAS
2019年第1期131-134,139,共5页
World Chinese Medicine
基金
广东省自然科学基金项目(20151248)
关键词
复方中药强骨饮
骨质疏松性椎体压缩性骨折
愈合程度
骨代谢
Compound Qianggu Decoction
Osteoporotic vertebral compressibility fracture
Degree of healing
Bone metabolism
