摘要
目的:探讨中药排石汤联合体外震波碎石术(ESWL)对肾结石患者肾功能、尿液代谢的影响。方法:选取2014年5月至2017年2月成都市龙泉驿区中医医院收治的肾结石患者138例为研究对象,按照随机数字表法分为观察组和对照组,每组69例,2组均行ESWL治疗,术后对照组采用常规药物治疗,观察组在对照组的基础上采用中药排石汤治疗,2组治疗时间均为2周。比较2组患者临床疗效及中医证候改善情况;统计手术前后2组患者肾功能及尿液代谢状况。结果:术后观察组总有效率为94. 20%,显著高于对照组的78. 26%(P <0. 05);与术前比较,2组患者中医证候积分均下降,且观察组低于对照组(P <0. 05);与术前比较,术后3～14 d 2组血清血肌酐(SCr)、尿素氮(BUN)、半胱氨酸蛋白酶抑制剂(Cys-C)、中性粒细胞明胶酶相关载脂蛋白(NGAL)水平均呈先升高后降低趋势,且各时间点观察组均低于对照组(P <0. 05);术后14 d观察组与术前比较,差异无统计学意义(P> 0. 05),对照组仍高于术前(P <0. 05);与术前比较,术后2周内2组患者高尿钙症、高草酸尿症、高尿酸尿症、低尿量及低镁尿症等尿液代谢异常发生率下降(P <0. 05),且观察组低于对照组(P <0. 05)。结论:中药排石汤联合ESWL治疗肾结石可保护患者肾功能,降低尿液代谢异常状况发生率,临床疗效显著。
Objective:To explore the influence of Chinese medicine Paishi Decoction combined with extracorporeal shock wave lithotripsy (ESWL) on the renal function and urine metabolism of patients with renal calculus.Methods:A total of 138 cases of patients with renal calculus from May 2014 to February 2017 were selected as study objects and were randomly divided into observation group (n=69) and control group (n=69).The 2 groups were treated with ESWL,control group was treated with routine drugs,and the observation group was treated with Paishi Decoction on the basis of control group.The 2 groups were treated for 2 weeks.The clinical efficacy and the improvement of Traditional Chinese Medicine syndrome of 2 groups were compared:the renal function index and urine metabolism condition of 2 groups were detected before and after operation.Results:The total effective rate of observation group reached up to 94.20% after operation,which was higher than that 78.26% of control group (P<0.01):Compared with before operation,the Traditional Chinese Medicine syndrome integral of 2 groups decreased after operation,and observation group were lower than control group (P<0.01):Compared with before operation,the levels of serum SCr,BUN,NGAL,Cys-C of 2 groups from 3 days to 14 days after operation increased firstly and then decreased,and observation group was lower than control group at each time point (P<0.01):There was no difference between 14 days after operation and before operation of observation group (P>0.05),but the control group was higher than those before operation (P<0.01).Compared with before operation,the incidence of urinary metabolic abnormalities such as high urinary calcium,phenylketonuria,hyperuricemia,low urine output and low magnesium decreased within 2 weeks after operation (P<0.05 or P<0.01),and observation group were lower than control group (P<0.01).Conclusion:Chinese medicine Paishi Decoction combined with ESWL in the treatment of renal calculus can protect the renal function of patients,reduce the incidence of urinary metabolic abnormalities,the clinical efficacy is remarkable.
作者
彭仁德
金涛
Peng Rende;Jin Tao(Department of Surgery,Longquanyi District Hospital of Traditional Chinese Medicine,Chengdu 610100,China;Department of Urology,Institute of Urology,Huaxi Hospital of Sichuan University,Chengdu 610100,China)
出处
《世界中医药》
CAS
2019年第1期162-165,共4页
World Chinese Medicine
基金
2015年四川省中医药管理局课题(2016Q042)
关键词
肾结石
体外震波碎石术
排石汤
肾功能
尿液代谢
Renal calculus
Extracorporeal shock wave lithotripsy
Paishi Decoction
Renal functions
Urine metabolism
