摘要
目的探讨复方黄柏液保留灌肠联合美沙拉嗪口服在治疗中度左半结肠型溃疡性结肠炎(UC)中的临床效果。方法选取2012年12月～2016年5月在阳信县人民医院诊断治疗的96例中度左半结肠型UC患者作为研究对象。按照随机数字表法将其分为美沙拉嗪组、黄柏液组及联合治疗组,每组各32例,分别给予美沙拉嗪肠溶片口服、复方黄柏液保留灌肠、美沙拉嗪肠溶片口服联合复方黄柏液保留灌肠治疗,总疗程为12周。比较三组患者的治疗总有效率、改良Mayo评分、血清白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)及超敏C反应蛋白(hs-CRP)水平及复发率。结果治疗12周后,联合治疗组患者的治疗总有效率高于美沙拉嗪组及黄柏液组,差异有统计学意义(P<0.05)。三组患者治疗后的血清hs-CRP、IL-6、IL-8、TNF-α水平及改良Mayo评分均低于治疗前,差异有统计学意义(P<0.05),且联合治疗组患者治疗后的血清hs-CRP、IL-6、IL-8、TNF-α水平及改良Mayo评分低于美沙拉嗪组及黄柏液组,差异有统计学意义(P<0.05)。随访半年,联合治疗组患者的复发率低于美沙拉嗪组及黄柏液组,差异有统计学意义(P<0.05)。结论复方黄柏液保留灌肠联合美沙拉嗪口服可明显提高中度左半结肠型UC患者临床效果。
Objective To investigate the clinical effect of Compound Phellodendron Liquid retention enema combined with Mesalazine orally in the treatment of moderate ulcerative colitis(UC)in left semicolon.Methods A total of 96 patients with moderate UC in left semicolon diagnosed and treated in People′s Hospital of Yangxin County from December 2012 to May 2016 were selected as subjects and were divided into 3 groups using the random number table method,with 32 cases in each group.Mesalazine were given as oral medicine in Mesalazine group.Compound Phellodendron Liquid retention enema were given in Phellodendron Liquid group.Mesalazine and Compound Phellodendron Liquid retention enema were both given to the patients in combined treatment group.The total effective rate,modified Mayo score,serum levels of interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP)and recurrence rate were compared among the three groups.Results After 12 weeks of treatment,the total effective rate of combined treatment group was higher than that of Mesalazine group and Phellodendron Liquid group,the differences were statistically significant(P<0.05).After treatment,the serum levels of hs-CRP,IL-6,IL-8,TNF-α and modified Mayo score in the three groups were significantly lower than those before treatment,the differences were statistically significant(P<0.05).The serum levels of hs-CRP,IL-6,IL-8,TNF-α and modified Mayo score in combined treatment group were lower than those in Mesalazine group and Phellodendron Liquid group,the differences were statistically significant(P<0.05).The rate of disease recurrence in combined treatment group was lower than that in Mesalazine group and phellodendron liquid group after six months of follow-up visit,the differences were statistically significant(P<0.05).Conclusion Compound Phellodendron Liquid retention enema combined with Mesalazine orally can effectively improve the treatment effect on patients with moderate UC in left semicolon.
作者
马天维
张红梅
庄晓惠
张兆美
MA Tian-wei;ZHANG Hong-mei;ZHUANG Xiao-hui;ZHANG Zhao-mei(Department of Gastroenterology,People′s Hospital of Yangxin County,Shandong Province,Yangxin 251800,China;Department of Gastroenterology,Affiliated Hospital of Weifang Medical University,Shandong Province,Weifang 261000,China)
出处
《中国当代医药》
2019年第1期176-179,共4页
China Modern Medicine
关键词
溃疡性结肠炎
复方黄柏液
保留灌肠
美沙拉嗪
Ulcerative Colitis
Compound Phellodendri Liquid
Retention enema
Mesalazien
