摘要
目的应用超声组织弥散定量分析技术检测乳腺癌术前TAC化疗者的肝脏组织弹性特征,为早期评估其肝脏损伤提供一种有效的定量检测方法。方法选取38例健康体检者(健康对照组)和35例经病理证实为乳腺癌需行6个周期TAC化疗的住院患者(化疗组),两组均行肝脏常规超声检查和超声组织弥散定量分析,测量肝纤维化指数(LFI)、蓝色区域面积百分比(%AREA)、应变均值(MEAN);并行肝功能实验室检查,比较化疗前两组间及化疗组不同化疗周期的检查结果。结果化疗前两组间各项超声弹性参数及肝功能指标比较差异均无统计学意义。与化疗前比较,化疗组患者化疗第2周期后,%AREA和LFI均增高(均P<0.05),血清谷氨酸转氨基酶(ALT)和天冬氨酸转氨基酶(AST)均呈上升趋势(均P<0.05);化疗第4周期和第6周期后,MEAN均减低,%AREA和LFI均增高,ALT和AST均升高(均P<0.05)。化疗组患者化疗第4周期与第2周期后比较,第6周期与第2周期后比较,第6周期与第4周期后比较,MEAN均减低,%AREA和LFI均增高(均P<0.05)。结论超声组织弥散定量分析技术能定量检测乳腺癌术前TAC化疗者肝组织的弹性特征;LFI%、AREA及MEAN有望成为定量检测TAC化疗乳腺癌患者早期肝脏损伤的有效指标。
Objective To probe an effective quantitative ultrasonic method for early assessment of liver injury for breast cancer patients treated with TAC before surgery by ultrasonic tissue dispersion quantitative analysis.Methods Thirtyeight healthy subjects were selected in the control group.Thirty-five hospitalized patients,pathologically proved to be breast cancer and required 6 cycles of TAC combined chemotherapy were enrolled in the chemotherapy group.Routine liver ultrasonography and tissue dispersion quantitative measurement were performed on both groups.Data of liver fibrosis index(LFI),the percentage of blue area(%AREA),the mean strain(MEAN)were measured and recorded.Liver function laboratory tests were perfomed,the results of tests between the two groups before chemotherapy and during different chemotherapy cycles in the chemotherapy group were compared.Results There was no significant difference in ultrasonic elastic parameters and liver function indexes between the two groups before chemotherapy.In the chemotherapy group,compared with the data before chemotherapy,LFI and%AREA were increased(both P<0.05),and ALT,AST had a tendency to increase,after the 2nd chemotherapy cycle.In the chemotherapy group,after the 4th cycle,MEAN was decreased,while %AREA and LFI were increased,and ALT,AST were increased(all P<0.05)compared with the data after the 2nd cycle.After the 6th cycle,MEAN was decreased,while %AREA and LFI were increased,and ALT,AST were increased(all P<0.05)compared with the data after the 2nd cycle and after the 4th cycle.Conclusion Ultrasonic elastography tissue dispersion quantitative analysis can be used to assess the elastic characteristics of liver tissue quantitively.LFI,%AREA and MEAN are expected to be effective indexes to evaluate early liver damage in breast cancer patients with TAC chemotherapy.
作者
张晓彤
尹丽
郭丽苹
ZHANG Xiaotong;YIN Li;GUO Liping(Department of Ultrasound,Shandong Provincial Third Hospital,Ji’nan 250000,China)
出处
《临床超声医学杂志》
CSCD
2019年第1期33-36,共4页
Journal of Clinical Ultrasound in Medicine
关键词
超声弹性成像
组织弥散定量分析
乳腺肿瘤
恶性
TAC化疗
肝脏损伤
Ultrasoundelastography
Tissuedispersionquantitativeanalysis
Breasttumor,malignant
TACchemotherapy
Liver damage
