摘要
目的分析感染巨细胞病毒(CMV)的溃疡性结肠炎(UC)患者的临床特征,并探讨影响UC患者感染CMV的相关危险因素。方法选取2015年9月-2018年4月在我院住院治疗的UC患者125例为研究对象,均经临床确诊,按照是否感染CMV将患者分为CMV组及无CMV组,比较两组的临床资料,通过Logistic进一步分析影响UC患者感染CMV的危险因素。结果 CMV组病程为(3.92±1.83)个月,明显短于无CMV组的(4.84±2.31)个月(P<0.05); CMV组住院天数为(21.96±5.12) d,明显长于无CMV组的(12.77±4.13) d(P<0.05);单因素分析结果显示:CMV组既往使用糖皮质激素、免疫抑制剂,发病后使用氨基水杨酸类、免疫抑制剂治疗、发热、并发症、纵行溃疡、深大溃疡、糖皮质激素治疗依赖及抑制人数、Hb、hs-CRP、ALB水平与无CMV组间差异有统计学意义(P<0.05); Logistic分析结果显示:既往使用糖皮质激素、使用氨基水杨酸类治疗、深大溃疡、Hb<100 g/L、hs-CRP<13 mg/L、ALB<32 g/L均为UC患者感染CMV的独立危险因素(P<0.05)。结论 Hb、hs-CRP、ALB水平及结肠镜下存在深大溃疡、使用糖皮质激素、使用氨基水杨酸类均为UC患者易感CMV的危险因素,临床应密切监控上述指标以预防感染,并及时给予对症治疗,防止病情恶化。
Objective To analyze the clinical characteristics of ulcerative colitis(UC) patients infected with cytomegalovirus(CMV),and to explore the risk factors for CMV infections in UC patients. Methods A total of 125 UC patients hospitalized between September 2015 and April 2018 were selected as subjects,all of whom were clinically confirmed. Patients were divided into CMV group and non-CMV group according to CMV infections. The clinical data of the two groups was analyzed and compared. The risk factors for CMV infections in UC patients were further identified by logistic regression. Results The course of disease in CMV group was(3.92±1.83) m,significantly shorter than that in non-CMV group [(4.84±2.31) m](P<0.05),while the length of hospital stay in CMV group was(21.96±5.12) d,significantly longer than that in non-CMV group [(12.77±4.13)d](P<0.05). Univariate analysis showed that there was significant difference in previous use of glucocorticoids and immunosuppressants,the use of aminosalicylic acid and immunosuppressive therapy after the onset of the disease,fever,complications,longitudinal ulcer,deep ulcer,effects of glucocorticoid therapy,and levels of Hb,hs-CRP and ALB between the two groups(P<0. 05). Logistic analysis showed that previous use of glucocorticoids and aminosalicylic acid,deep and large ulcers,Hb<100 g/L,hs-CRP<13 mg/L and ALB<32 g/L were independent risk factors for CMV infections in UC patients(P<0.05). Conclusion The levels of Hb,hs-CRP,ALB,presence of deep ulcers under colonoscopy,and the use of glucocorticoid and aminosalicylic acid are all the risk factors for the susceptibility to CMV in patients with UC. The above indexes should be closely monitored in clinic to prevent infections and treat the disease without delay to prevent the deterioration of the disease.
出处
《解放军预防医学杂志》
CAS
2019年第1期28-31,共4页
Journal of Preventive Medicine of Chinese People's Liberation Army
基金
四川省广元市卫计委资助项目(No.201500178S)
