摘要
睡眠呼吸暂停综合征(sleep apnea hypopnea syndrome,OSAHS)是临床常见的睡眠呼吸疾病,主要临床表现为睡眠中出现呼吸气量降低或是呼吸暂停,而且部分患者会伴有打鼾症状,当患者长时间持续出现间断呼吸气量降低或呼吸暂停时,就会导致机体出现间歇性低氧,致使组织缺氧,引发机体氧化应激反应、炎性反应等。类风湿性关节炎(rheumatoid arthritis,RA)是一种全身性疾病,累及关节滑膜增生、软骨糜烂和关节损伤。在类风湿性关节炎发病机制中起关键作用的是滑膜衬里层成纤维样滑膜细胞(fibroblast like synoviocytes,FLS),该病症主要就是机体一系类炎症反应导致患者关节损伤,出现关节功能障碍,影响患者的生活质量。本文首先概述了类风湿性关节炎的疾病特性,分析了类风湿性关节炎伴睡眠呼吸暂停综合征的发病机制,探讨了类风湿性关节炎与睡眠呼吸暂停之间的关系,并重点论述了类风湿性关节炎伴睡眠呼吸暂停综合征的治疗进展。
Sleep apnea hypopnea syndrome(OSAHS)is a common clinical sleep-disordered disease.The main clinical manifestations are decreased respiratory volume or apnea during sleep,and some patients may have snoring symptoms.If patients continue to have the intermittent respiratory volume reduction or apnea for a long time,it will lead to intermittent hypoxia in the body,result in tissue hypoxia and cause the body's oxidative stress and inflammatory reactions.Rheumatoid arthritis(RA)is a systemic disease involving joint synovial hyperplasia,cartilage erosion,and joint damage.Fibroblast like synoviocytes(FLS)play a key role in the pathogenesis of rheumatoid arthritis.This disease is mainly caused by a series of inflammatory reactions in the body,leading to joint damage and joint function.Obstacles affect the quality of life of patients.This article first summarizes the disease characteristics of rheumatoid arthritis,analyzes the pathogenesis of rheumatoid arthritis with sleep apnea syndrome,discusses the relationship between rheumatoid arthritis and sleep apnea,and focuses on progress in the treatment of rheumatoid arthritis with sleep apnea syndrome.
作者
肖剑伟
蔡旭
郭粉莲
洪易炜
尹志华
陈新鹏
戴莉萍
叶志中
XIAO Jian-wei;CAI Xu;GUO Feng-lian;HONG Yi-wei;YIN Zhi-hua;CHEN Xin-peng;DAI Li-ping;YE Zhi-zhong(Department of Rheumatology,Shenzhen Futian Hospital for Rheumatic Diseases,Shenzhen 518000,Guangdong,China)
出处
《海南医学院学报》
CAS
2019年第2期157-160,共4页
Journal of Hainan Medical University
基金
2016年深圳市卫生计生系统科研项目(201606048)
深圳市医疗卫生三名工程(SZSM201602087)
2018福田区卫生公益性科研项目(FTWS2018066)~~
