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右美托咪啶用于老年腹部手术患者术后镇痛临床观察 被引量:4

Clinical observation of dexmedetomidine for postoperative analgesia in elderly patients undergoing abdominal surgery
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摘要 右美托咪啶(DEX)是一种高选择性的α2受体激动剂,具有镇静、镇痛、抗焦虑和交感神经抑制的作用,同时对呼吸无抑制作用[1-5]。老年人是临床麻醉中较为特殊的一类人群,其往往存在呼吸、循环等多器官的合并症,临床用药的选择较其他人群需更加慎重,其术后镇痛的选择也需充分评估可能发生的并发症,尽量减少由阿片类药物引发的呼吸、循环抑制。围术期应用右美托咪啶可以减少阿片类药物的剂量,降低阿片类药物相关并发症[6-7]。
出处 《浙江中西医结合杂志》 2019年第2期126-130,共5页 Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
基金 浙江省医学会临床科研资金项目(No.2015ZYC-A42)
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  • 1李民,张利萍,吴新民.右美托咪啶在临床麻醉中应用的研究进展[J].中国临床药理学杂志,2007,23(6):466-470. 被引量:483
  • 2佘守章,李慧玲,许学兵,莫世湟.右旋美托咪啶的镇静效应及其对全麻镇静深度的影响[J].临床麻醉学杂志,2006,22(1):10-12. 被引量:105
  • 3Chernik DA,Gillings D,Laine H,et al.Validity and reliability of the observer's assessment of alertness/sedation scale:study with intravenous midazolam.J Clin Psychopharmacol,1990,10:244-251.
  • 4Khan ZP,Ferguson CN,Jones RM.Alpha-2 and imidazoline receptor agonist:their pharmacology and therapeutic role.Anesthesia,1999,54:146-165.
  • 5Granholm M,McKusick BC,Westerholm FC,et al.Evaluation of the clinical efficacy and safety of dexmedetomidine or medetomidine in cats and their reversal with atipamezole.Veterinary anaesthesia and analgesia,2006,339:214-223.
  • 6Ebert TJ,Hall JE,Bamey JA,et al.The effects of increasing plasma concentrations of dexmedetomidine in humans.Anesthesiology,2000,93:382-394.
  • 7Bloor BC,Ward DS,Belleville JP,et al.Effects of intravenous dexmedetomidine in humans,Ⅱ:hemodynamic changes.Anesthesiology,1992,77:1134-1142.
  • 8Nelson LE,Lu J,Guo TZ,et al.The α2-Adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects.Anesthesiology,2003,98:428-436.
  • 9Gil DW, Cheevers CV, Kedzie KM, Manlapaz CA, Rao S, Tang E, Donello ]E: Alpha-l-adrenergic receptor agonist activi- ty of clinical alpha-adrenergic receptor agonists interferes with alpha-2-mediated analgesia[J]. Anesthesiology, 2009, 110(2) :401-407.
  • 10Massad IM, Mohsen WA, Basha AS, A1-Zaben KR, AI-Musta- fa MM, Alghanem SM: A balanced anesthesia with dexmedeto- midine decreases postoperative nausea and vomiting after laparo- seopic surgery[J]. Saudi Med J, 2009, 30(12) :1537-1541.

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