摘要
目的探讨炎琥宁注射液结合西医常规疗法治疗小儿病毒性脑炎的疗效,以及对患儿免疫功能、炎症反应及抗氧化的影响。方法选取85例病毒性脑炎患儿为研究对象,随机分为观察组43例和对照组42例。对照组采用西医常规疗法,观察组在西医常规疗法基础上联合炎琥宁注射液治疗,疗程均为7d。比较两组疗法临床疗效,以及治疗前后T淋巴细胞亚群、免疫球蛋白(IgA、IgG、IgM)以及血清IL-6、TNF-α、SOD、MDA的变化情况。结果疗程结束后,观察组总有效率为93.02%,显著高于对照组(P<0.05);观察组发热等临床症状改善时间均明显短于对照组(P<0.001);两组T细胞亚群CD3+、CD4+、CD8+值和免疫球蛋白值(IgA、IgG、IgM)较治疗前均明显增加,观察组增加程度较对照组更加明显(P<0.05);两组血清IL-6、TNF-α、MDA值较治疗前均明显减少,观察组减少程度较对照组更加明显(P<0.05),两组血清SOD值较治疗前均明显增加,观察组增加程度较对照组更加明显(P<0.05)。结论炎琥宁注射液结合西医常规疗法对病毒性脑炎患儿的疗效显著,并可改善患儿免疫功能,并具有一定的抗炎及抗氧化功能。
Objective To evaluate the clinical efficacy of potassium sodium dehydroandroan drographolide succinate combined with routine treatment of western medicine in child viral encephalitis, and the impact on the immune function, inflammatory reaction and antioxidation in the serum. Methods 85 child with viral encephalitis were collected and randomly divided into group control (42 cases) and group observation (43 cases). The group control was treated with routine treatment of western medicine, and the group observation was treated with potassium sodium dehydroandroan drographolide succinate combined with routine treatment of western medicine. All groups had a 7 days course of treatment. The clinical efficacy, the changes of T lymphocyte subsets(CD3 +, CD4 +, CD8 +), immunoglobulins (IgA, IgG and IgM) and IL-6, TNF-α, SOD and MDA in the serum before and after treatment were observed and compared. Results The total effective rate of group observation was 93.02%,which was significantly higher than the group control( P <0.05). The time of group observation in improvement of clinical symptoms was significantly shorter than that in the group control( P <0.001). The serum levels of CD3^+, CD4^+, CD8^+, IgA, IgG, IgM and SOD in two groups after treatment were significantly increased than before ( P <0.05). The serum levels of IL-6, TNF-α and MDA in two groups were significantly decreased after treatment( P <0.05). In addition, the degree of improvement in group observation was more obvious than that of group control. Conclution There was a significant clinical efficacy of potassium sodium dehydroandroan drographolide succinate combined with routine treatment of western medicine in child viral encephalitis, which could improve the immune function and had a certain antiinflammatory and antioxidant function.
作者
郑诺
刘晓鸣
ZHENG Nuo;LIU Xiaoming(Children Hospital of Xuzhou, Xuzhou 221000, Jiangsu , China)
出处
《西部医学》
2019年第1期91-94,共4页
Medical Journal of West China
基金
江苏省妇幼健康科研项目(F201355)
关键词
炎琥宁
病毒性脑炎
小儿
血清学指标
Potassium sodium dehydroandroan drographolide succinate
Viral encephalitis
Infant
Serum indexes
