摘要
目的探讨抗结核药物治疗所致肝损伤患者的危险因素及其治疗转归。方法回顾性分析我院自2013年1月～2017年1月收治的1033例抗结核治疗患者的临床资料,其中158例患者发生抗结核药物所致肝损伤(DILD),统计分析所有患者性别、年龄、肝病史、酗酒、营养不良、痰菌情况。采用Logistics多因素回归分析法分析患者发生DILD的危险因素及治疗转归情况。结果1033例抗结核治疗患者中,出现DILD为158例,发生率15.30%,年龄、肝病史、酗酒、营养不良、痰菌阳性是DILD的危险因素(P<0.05);158例DILD患者经治疗后,治疗成功150例(94.94%),治疗失败8例(5.06%)。结论年龄、肝病史、酗酒、营养不良、痰菌阳性是DILD的危险因素,临床上应重点监测危险人群用药情况,及时调整治疗方案,降低DILD发生率,促使患者顺利完成化疗。
Objective To investigate the risk factors and treatment outcomes of patients with liver injury caused by anti-tuberculosis drugs.Methods The clinical data of 1033 anti-tuberculosis patients admitted to our hospital from January 2013 to January 2017 were retrospectively analyzed.Among them,158 patients developed liver damage caused by anti-tuberculosis drugs(DILD),and all patients were statistically analyzed.Age,history of liver disease,alcoholism,malnutrition,and sputum.Logistics multivariate regression analysis was used to analyze the risk factors and treatment outcomes of patients with DILD.Results Among 1033 anti-tuberculosis patients,158 cases had DILD,the incidence rate was 15.30%.Age,liver disease history,alcoholism,malnutrition,and sputum positive were risk factors for DILD(P<0.05).After treatment of 158 patients with DILD,150 patients(94.94%)were successfully treated and 8 patients(5.06%)were treated with failure.Conclusion Age,liver disease history,alcoholism,malnutrition,and sputum positive are risk factors for DILD.Clinically,it is necessary to monitor the drug use of dangerous people,adjust the treatment plan in time,reduce the incidence of DILD,and prompt patients to successfully complete chemotherapy.
作者
李新刚
LI Xin-gang(Department of Tuberculosis No. 2,Jiamusi Tuberculosis Control Institute,Jiamusi154002,Heilongjiang,China)
出处
《医学信息》
2019年第3期155-157,共3页
Journal of Medical Information
关键词
抗结核药物
肺结核
肝损伤
危险因素
治疗转归
痰菌阳性
Anti-tuberculosis drugs
Tuberculosis
Liver injury
Risk factors
Treatment outcome
Sputum positive
