摘要
目的探讨甲状腺癌中骨桥蛋白(OPN)、E-钙黏蛋白、β-连环蛋白的表达及其与预后的关系。方法选取58例甲状腺癌患者,取其病理确诊的甲状腺癌组织及癌旁> 2 cm处的正常甲状腺组织,检测两者OPN、E-钙黏蛋白、β-连环蛋白的表达情况。分析OPN、E-钙黏蛋白、β-连环蛋白的表达情况与甲状腺癌临床病理参数及预后的相关性。结果甲状腺癌组织中OPN、β-连环蛋白的阳性表达率均高于正常甲状腺组织(均P <0. 05),E-钙黏蛋白的阳性表达率低于正常甲状腺组织(P <0. 05)。在甲状腺癌组织中,OPN的表达情况与性别、年龄无关(均P>0. 05),与病理分型、分化程度、肿瘤分期、包膜浸润、淋巴结转移均相关(均P <0. 05);E-钙黏蛋白与β-连环蛋白的表达情况与性别、年龄、病理分型、分化程度、肿瘤分期均无关(均P> 0. 05),与包膜浸润、淋巴结转移均相关(均P <0. 05); OPN的表达情况与E-钙黏蛋白具有相关性(P <0. 05),与β-连环蛋白无相关性(P>0. 05); E-钙黏蛋白的表达情况与β-连环蛋白具有相关性(P <0. 05)。OPN表达阳性患者的5年生存率低于OPN表达阴性患者(P <0. 05)。结论甲状腺癌中OPN和β-连环蛋白的表达上调而E-钙黏蛋白的表达下调。OPN、E-钙黏蛋白、β-连环蛋白的表达情况与甲状腺癌的发生、发展及转移密切相关,可作为甲状腺癌早期诊断的标记物及潜在治疗靶点。
Objective To investigate the expressions of osteopontin(OPN),E-cadherin andβ-catenin in thyroid carcinoma and their relationship with prognosis.Methods A total of 58 patients with thyroid carcinoma were selected and thyroid carcinoma tissues pathologically diagnosed and normal thyroid tissues more than 2 cm adjacent to the cancer were taken,and the expressions of OPN,E-cadherin andβ-catenin were detected in both types of tissues.The correlations between the expressions of OPN,E-cadherin andβ-catenin and the clinicopathological parameters and prognosis of thyroid carcinoma were analyzed.Results The positive expression rates of OPN andβ-catenin were higher in thyroid carcinoma tissues than in normal thyroid tissues(all P<0.05),and the positive expression rate of E-cadherin was lower in thyroid carcinoma tissues than in normal thyroid tissues(P<0.05).In thyroid carcinoma tissues,the expression status of OPN was not related to gender or age(all P >0.05),but was related to pathological type,degree of differentiation,tumor stage,capsule infiltration and lymph node metastasis(all P<0.05);the expressions of E-cadherin andβ-catenin were not related to gender,age,pathological type,degree of differentiation,or tumor stage(all P >0.05),but were related to the capsule infiltration and lymph node metastasis(all P<0.05);the expression of OPN was related to E-cadherin(P<0.05),but not related toβ-catenin(P<0.05),and the expression of E-cadherin was related toβ-catenin(P<0.05).The 5-year survival rate of OPN positive patients was lower than that of OPN negative patients.Conclusion The expressions of OPN and E-cadherin increase,while the expression ofβ-catenin decreases in thyroid carcinoma.They are closely related to the occurrence,development and metastasis of thyroid carcinoma,and might be used as diagnostic markers and potential therapeutic targets for thyroid carcinoma.
作者
赵文辉
ZHAO Wen-hui(Department of Pathology,the Affiliated Hospital of Qinghai University,Xining 810000,China)
出处
《广西医学》
CAS
2019年第1期48-51,66,共5页
Guangxi Medical Journal
