摘要
目的观察乙型肝炎肝硬化失代偿期应用恩替卡韦抗病毒治疗的效果、安全性及对患者肝功能的影响。方法选取2016年12月至2017年12月本院收治的乙型肝炎肝硬化失代偿期患者76例,以随机分组法将其分为对照组和观察组,各38例。对照组采取拉米夫定治疗,观察组采取恩替卡韦抗病毒治疗,比较两组治疗效果及安全性。结果观察组治疗总有效率高于对照组(P<0.05)。治疗后,两组肝功能各项指标均明显改善,且观察组显著优于对照组(P<0.05);两组各临床症状评分均降低,且观察组显著低于对照组(P<0.05);两组肝纤维化指标水平和临床观察指标评分均降低,且观察组低于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论乙型肝炎肝硬化失代偿期患者采用恩替卡韦抗病毒治疗,对改善肝功能、缓解临床症状、提高治疗效果具有积极作用,值得临床推广应用。
Objective To observe the effect and safety of entecavir antiviral therapy on decompensation of hepatitis B cirrhosis and its impact on liver function of patients.Methods A total of 76 patients with decompensated hepatitis B cirrhosis admitted in our hospital from December 2016 to December 2017 were randomly divided into control group and observation group,with 38 cases in each group.The control group received lamivudine treatment,and the observation group received entecavir antiviral therapy.The therapeutic effects and safety of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than in the control group(P<0.05).After treatment,the liver function indexes of both groups significantly improved,and those of the observation group were significantly better than the control group(P<0.05);the various clinical symptom scores of both groups decreased,and those of the observation group were significantly lower than the control group(P<0.05),the levels of liver fibrosis indexes and scores of clinical observation indexes decreased in both groups,and those of the observation group were lower than the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P >0.05).Conclusion Entecavir antiviral in the treatment of decompensation of hepatitis B eirrhosis have a positive effect on improving liver function,relieving clinical symptoms and improving treatment effect,and are worthy of clinical promotion and application.
作者
吉胜利
JI Sheng-li(No.2 Internal Medicine Department,Traditional Chinese Medicine Hospital of Huazhou District,Weinan 714100,China)
出处
《临床医学研究与实践》
2019年第4期35-37,共3页
Clinical Research and Practice
