摘要
目的探讨益气补肾活血方联合米非司酮以及米索前列醇治疗稽留流产的临床疗效,进一步评价其有效性及安全性。方法 180例稽留流产患者,根据患者意愿及不同的临床用药治疗方式分为对照组和研究组,每组90例。对照组采用米非司酮联合米索前列醇治疗,如患者流产失败或不完全流产,则采取常规清宫术治疗,研究组给予患者口服米非司酮、米索前列醇联合补肾益气活血方治疗,如患者出现流产失败现象则给予常规清宫术治疗,观察2组患者妊娠物排出时间、腹痛持续时间、阴道不规则出血量,并对2组患者的完全流产率、不完全流产率以及流产失败率和不良反应发生率比较,进行统计分析。结果治疗前2组患者的性别、年龄及孕周经比较,差异无统计学意义(P> 0. 05)。治疗后研究组妊娠物排除时间、腹痛持续时间、阴道不规则出血量、完全流产率均明显优于对照组(P <0. 05),研究组的不完全流产率、流产失败率及不良反应发生率明显低于对照组(P <0. 05)。结论采用益气补肾活血方联合米非司醇、米索前列醇治疗稽留流产患者的临床有效率高,可加速妊娠物的排出,减少患者的出血量及腹痛持续时间,提高完全流产率,降低患者的不完全流产率、流产失败率及不良反应发生率,对患者的远期预后佳,可有效减轻稽留流产对患者自身造成的伤害,安全系数较高,值得临床进一步推广应用。
Objective To investigate the therapeutic effects of Yiqibushenhuoxue prescription combined with mifepristone and misoprostol on missed abortion,and to evaluate its efficacy and safety.Methods A total of 180 patients with missed abortion who were admitted and treated in our hospital from January 2016 to July 2017 were enrolled in the study.According to the different medication methods these patients were divided into control group and research group.The patients in control group were treated by mifepristone combined with misoprostol,if the patients were underwent abortion failure or incomplete abortion,they were trated by curettage,however,the patients in research group were treated by Yiqibushenhuoxue prescription combined with mifepristone and misoprostol,if the patients underwent abortion failure or incomplete abortion,they were trated by curettage.The discharging time of pregnancy matters,duration of abdominal pain,vaginal irregular blood loss,complete abortion rate,incomplete abortion rate,abortion failure rate and incidence of adverse reactions were observed and compared between the two groups.Results Before treatment there were no significant differences in patient’s gender,age and gestational weeks between the two groups(P >0.05).After treatment discharging time of pregnancy matters,duration of abdominal pain,vaginal irregular blood loss,complete abortion rate in research group were superior to those in control group(P<0.05),moreover,the incomplete abortion rate,abortion failure rate and incidence of adverse reactions in research group were significantly lower than those in control group(P<0.05).Conclusion The therapeutic effects of Yiqibushenhuoxue prescription combined with mifepristone and misoprostol on missed abortionare quite significant,which can can accelerate the discharging of pregnancy matters,reduce the bleeding volume and duration of abdominal pain,increase complete abortion rate,lower incomplete abortion rate,abortion failure rate and incidence of adverse reactions,with good safety,therefor,it is worthy of further clinical application and promotion.
作者
姜瑞花
贾梅
杨久梅
王淑婧
李书哲
高永强
徐海明
JIANG Ruihua;JIA Mei;YANG Jiumei(Department of Obstetrics and Gynecology,TCM Hospital of Wen’an County,Hebei,Wen’an 065800,China)
出处
《河北医药》
CAS
2019年第2期230-232,236,共4页
Hebei Medical Journal
基金
廊坊市科技局科技计划项目(编号:2017013160)
关键词
益气补肾活血方
米非司醇
米索前列醇
稽留流产
临床研究
Yiqibushenhuoxue prescription
mifepristone
misoprostol
missed abortion
clinical research
