摘要
目的探讨胸腺肽辅助治疗对秋季腹泻患儿血浆T淋巴细胞亚群的影响。方法选取2014年1月至2017年1月收治的秋季腹泻患儿100例,依据随机数字表法分为辅疗组和常规组,每组50例。常规组给予常规对症治疗,辅疗组在此基础上给予胸腺肽辅助治疗,比较2组血浆T淋巴细胞亚群(CD_3^+、CD_4^+、CD_8^+、CD_4^+/CD_8^+)、临床症状、治疗疗效、不良反应、复发。结果 2组治疗后CD_3^+、CD_4^+、CD_4^+/CD_8^+水平明显高于治疗前,辅疗组治疗后CD_3^+、CD_4^+、CD_4^+/CD_8^+水平明显高于常规组,差异有统计学意义(P <0. 05);辅疗组退热、大便次数复常、大便性状复常、脱水纠正时间明显低于常规组,差异有统计学意义(P <0. 05);辅疗组治疗有效率明显高于常规组,差异有统计学意义(P <0. 05);辅疗组和常规组不良反应发生率差异无统计学意义(P> 0. 05);随访12个月,辅疗组复发率明显低于常规组,差异有统计学意义(P <0. 05)。结论胸腺肽辅助治疗可有效改善秋季腹泻患儿血浆T淋巴细胞亚群和临床症状,有利于提高治疗疗效和减少复发,且具有良好的安全性,值得临床作进一步推广。
Objective To investigate the effects of thymosin adjuvant therapy on the plasma T lymphocyte subsets in children with autumn diarrhea. MethodsA total of 100 children with autumn diarrhea who were admitted and treated in our hospital from January 2014 to January 2017 were enrolled in the study. According to the random number table methord, these patients were divided into adjuvant treatment group ( n =50) and conventional treatment group ( n =50). The patients in conventional group were given routine symptomatic treatment, on this basis, the patients in adjuvant treatment group were given thymosin adjuvant treatment. The plasma T lymphocyte subsets levels (CD3^+, CD4^+, CD8^+,CD4^+/CD8^+), the clinical symptoms, curative effects, adverse reaction and recurrence rate were observered and compared between the two groups. ResultsAfter treatment the levels of CD3^+,CD4^+,CD4^+/CD8^+ in both goups were significantly higher than those before treatment ( P <0.05), moreover, the levels of CD3^+,CD4^+,CD4^+/CD8^+ in adjuvant treatment group were significantly higher than those in conventional group ( P <0.05). The abatement of fever, defecate frequency recovery, stool property recovery, correcting time of dehydration in adjuvant treatment group were significantly lower than those in conventional treatment group ( P <0.05). The effective rate in adjuvant treatment group was significantly higher than that in conventional group ( P < 0.05 ). There was no significant difference in incidence rate of adverse reactions between the two groups ( P >0.05). After 12-month follow up, the recurrence rate in adjuvant treatment group was significantly lower than that in conventional treatment group ( P <0.05). ConclusionThymosin adjuvant therapy can effectively improve the plasma T lymphocyte subsets and clinical symptoms of children with autumn diarrhea, which is beneficial to improve therapeutic effects and reduce the recurrence rate,with good safety,therefor, it is worth of further clinical promotion.
作者
魏有花
孔广玺
盛小梅
WEI Youhua;KONG Guangxi;SHENG Xiaomei(Qinghai Welfare Charity Hospital,Qinghai, Xining 811000,China)
出处
《河北医药》
CAS
2019年第1期103-105,109,共4页
Hebei Medical Journal
