摘要
目的:观察雷火灸对食管癌患者放疗后外周血血清转化生长因子-β1(TGF-β1)水平及肿瘤患者生活质量的影响。方法:选取40例确诊为食管癌的患者,随机分为治疗组20例和对照组20例,两组均常规放疗基础治疗,治疗组在对照组的基础上予雷火灸治疗;比较放疗开始前、放疗结束时及放疗结束后3个月两组患者生活质量(QOL)评分、肝肾功能损害情况、血清TGF-β1的变化情况。结果:放疗结束时及放疗结束后3个月治疗组QOL评分均高于对照组(P <0. 01);放疗结束时及放疗结束后3个月TGF-β1水平均低于对照组,但仅放疗结束后3个月差异具有统计学意义(P <0. 01);两组各阶段谷丙转氨酶(U/L)、谷草转氨酶(U/L)、尿素氮(mmol/L)、肌酐(umol/L)数值差异均不具有统计学意义。结论:雷火灸能提高食管癌患者的生活质量,可能是通过抑制TGF-β1的表达来实现。
Objective:To observe the effect of thunder-fire moxibustion on serum level of transforming growth factor-β1(TGF-β1)and the quality of life(QOL)in patients with esophageal cancer after radiotherapy.Methods:40 patients with esophageal cancer were randomly divided into the treatment group(n=20)and the control group(n=20).The control group was treated with conventional radiotherapy;on which basis,the treatment group was also treated with thunder-fire moxibustion.The QOL scores,liver and kidney function,and serum TGF-β1 were compared between the two groups before the radiotherapy,at the end of the radiotherapy,and three months after the radiotherapy.Results:The QOL scores of the treatment group were significantly higher than those of the control group at the end of the radiotherapy and three months after the radiotherapy(P<0.01).The TGF-β1 level of the treatment group was lower than that of the control group at the end of the radiotherapy and three months after radiotherapy;the difference was statistically significant three months after the radiotherapy between the groups(P<0.01).There were no statistical differences between the two groups in the values of glutamic-pyruvic transaminase,glutamic oxalacetic transaminase,urea nitrogen,and creatinine.Conclusion:Thunder-fire moxibustion can improve QOL of the patients with esophageal cancer,which may be achieved by inhibiting the expression of TGF-β1.
作者
陈超
陈理
CHEN Chao;CHEN LI(The Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China)
出处
《针灸临床杂志》
2018年第12期43-46,共4页
Journal of Clinical Acupuncture and Moxibustion
关键词
雷火灸
食管癌
血清转化生长因子-Β1
生活质量
Thunder-fire moxibustion
Esophagus cancer
Serum transforming growth factor-β1
Quality of life
