摘要
目的:分析研究美沙拉嗪联合双歧杆菌三联活菌治疗轻中度溃疡性结肠炎的效果及对CPR、ESR水平的影响。方法:以我院2016年12月-2017年12月收治的100例轻中度溃疡性结肠炎患者为研究对象,随机分为对照组和试验组,每组各50例。对照组患者给予美沙拉嗪单药治疗,试验组患者给予美沙拉嗪加服双歧杆菌三联活菌治疗,两组的治疗时间均为60 d。比较治疗前后,两组患者的C反应蛋白(CPR)水平、红细胞沉降率(ESR)水平以及Rachmilewitz评分。结果:治疗后,两组患者的CPR、ESR水平均较治疗前低,试验组患者的CPR、ESR水平均低于对照组,分别为(18.6±3.4)mg/L、(16.6±3.6)mm/h,差异有统计学意义(均P <0.05);两组患者的Rachmilewitz评分在治疗后亦均有所降低,且试验组患者的Rachmilewitz评分(2.3±0.5分)显著低于对照组(3.5±0.7分),经统计学对比,差异显著(χ2=9.864,P <0.05)。结论:采用美沙拉嗪联合双歧杆菌三联活菌治疗轻中度溃疡性结肠炎疗效显著,可明显改善患者的CPR、ESR水平,加快溃疡的愈合。
Objective:To analyze the effect of mesalazine combined with Bifidobacterium triplex in treating mild and moderate ulcerative colitis and its effect on CPR and ESR levels.Methods:100 cases of mild and moderate ulcerative colitis patients admitted to our hospital from December 2016 to December 2017 were randomly divided into the control group and the experimental group,with 50 cases in each group.The control group was given a single drug treatment of mesalazine,and the experimental group was given a treatment of mesalazine plus triplex bacteria,and the treatment time of both groups was 60 d.Before and after the treatment,the levels of C-reactive protein(CPR),erythrocyte sedimentation rate(ESR)and Rachmilewitz scores were compared in two groups.Results:After the treatment,the average CPR and ESR levels decreased in the two groups of patients,and the CPR and ESR levels in the experimental group decreased more significantly compared with that of the control group,which were 18.6±3.4 mg/L and 16.6±3.6 mm/h respectively.In the experimental group who received the treatment of mesalazine plus Bifidobacterium,the Rachmilewitz score(2.3±0.5)decreased more significantly compared with that of the control group(3.5±0.7),the difference between two groups was of statistical significance(χ^2=9.864,P<0.05).Conclusion:The treatment of mild and moderate ulcerative colitis with mesalazine combined with Bifidobacterium was effective,and it could obviously improve the CPR and ESR levels of patients and accelerate the healing of ulcer.
出处
《中医临床研究》
2018年第36期61-62,共2页
Clinical Journal Of Chinese Medicine
