摘要
目的探讨外周血红细胞分布宽度(red blood cell distribution width,RDW)在儿童手足口病(hand-foot-mouth dis-ease,HFMD)中与疾病严重程度的相关性。方法选择台山市人民医院2015年1月1日～2018年3月31日住院的手足口病儿童374例,其中手足口病普通病例336例,手足口病重症病例38例,检测手足口病普通病例与重症病例RDW并分析其与病情严重程度的相关性。结果①手足口病重症组的小儿危重病例评分(PCIS)小于普通组(75.9±6.4vs 83.9±5.6,P<0.001),重症病例组的RDW高于普通组[(15.7±1.5)%vs(14.3±1.3)%,P<0.001],重症病例组的CRP高于普通组[(26.6±9.4)mg/L vs(16.4±3.8)mg/L,P<0.001],重症组的血糖高于普通组[(9.6±2.9)mmol/L vs(7.8±2.0)mmol/L,P<0.001],差异均有统计学意义。②相关性分析显示,RDW与PCIS评分呈负相关(r=-0.33,P<0.001),RDW与超敏C反应蛋白呈正相关关系(r=0.139,P=0.007)。③RDW识别重症病例的ROC曲线下面积为0.763,其95%的置信区间为[0.689,0.838],最佳截断值是14.1%,此时灵敏度为0.947,特异度为0.482;血糖的ROC曲线下面积为0.700,其95%的置信区间为[0.601,0.798],最佳截断值是9.25mmol/L,此时灵敏度为0.605,特异度为0.789。结论 RDW与儿童手足口病的严重程度密切相关,随病情严重程度的加重而升高,有助于儿童手足口病的严重程度评估,为临床上识别手足口病重症病例提供了一个新的廉价且便捷的指标。
Objective To explore the correlation between the distribution width of peripheral blood red blood cells and the severity of disease in children with Hand-foot-mouth disease(HFMD).Methods From the first of January 2015 to the thirtyfirst of March 2018,374 cases of children with HFMD who were hospitalized in Taishan People’s Hospital were collected and assigned as 2 groups.The patients were divided into ordinary group(n=336)and severe group(n=38).Recording various observing data and doing statistical analysis.Results①Compared with ordinary group,PCIS,RDW,CRP and blood glucose levels in serve group with statistical significance[the periods of illness(d):PCIS:75.9±6.4 vs 83.9±5.6;RDW(%):(15.7±1.5)vs(14.3±1.3);CRP:(26.6±9.4)mg/L vs(16.4±3.8)mg/L;blood glucose levels:(9.6±2.9)mmol/L vs(7.8±2.0)mmol/L,all P<0.001].②The correlation analysis between RDW and PCIS showed that RDW was significantly negatively correlated with PCIS(r=-0.33,P=0.000),and postively related with CRP(r=0.139,P=0.007).③ROC curve analysis showed that RDW could be used to prediction for severe case of HDMF,the area under the ROC curve(AUC)was 0.763.When threshold value of RDW was 14.1%,the sensitivity was 94.7%,and the specificity was 48.2%.Conclusion RDW is a useful marker for evaluate the condition of HFMD.That suggests that RDW can be used as a cheap and convenient index for identifying severe cases of HFMD.
作者
刘玉嫦
李小玲
黄艳琼
LIU Yu-chang;LI Xiao-ling;HUANG Yan-qiong(Department of Pediatric,Taishan People’s Hospital,Guangdong J iangmen 529200,China)
出处
《现代检验医学杂志》
CAS
2019年第1期85-88,共4页
Journal of Modern Laboratory Medicine
关键词
儿童
手足口病
红细胞分布宽度
children
hand-foot-mouth disease
red blood cell distribution width
