期刊文献+

自噬基因Beclin1对乳腺癌作用的研究进展 被引量:6

Research progress on the effect of autophagy-related gene Beclin1 on breast cancer
下载PDF
导出
摘要 自噬是指胞浆内大分子物质和细胞器在膜包囊泡中大量降解的生物学过程,在维持细胞内稳态、调控细胞分化及对环境应激的应答方面极为关键。Beclin1为重要的自噬相关基因,目前研究发现其对乳腺癌的发生发展起着双向作用。本文对近年来Beclin1对乳腺癌作用的研究进展进行综述。 Autophagy is a process that regulates the degradation of cytoplasmic macromolecular substances and organelles,and its role is crucial in maintaining cell homeostasis,cell differentiation,and response to environmental stress.With the deepening of research,we found Beclin1,which was an important autophagy-related gene,played a bidirectional role in the occurrence and development of breast cancer.We review the research progress on the effect of autophagy-related gene Beclin1 on breast cancer.
作者 陈品珍 杨丁丁 陈兴宇 申可佳 CHEN Pinzhen;YANG Dingding;CHEN Xingyu;SHEN Kejia(Department of Immunology,Medical College,Hunan University of Chinese Medicine,Changsha 410208,China)
出处 《临床肿瘤学杂志》 CAS 北大核心 2019年第1期87-91,共5页 Chinese Clinical Oncology
基金 国家自然科学基金资助项目(81303003)
关键词 自噬 BECLIN1 乳腺癌 Autophagy Beclin1 Breast cancer
  • 相关文献

参考文献12

二级参考文献56

  • 1Yang Cao Daniel J Klionsky.Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein[J].Cell Research,2007,17(10):839-849. 被引量:103
  • 2Foulkes WD, Smith IE, Reis-Filho JS. Triple-negative breast cancer[J]. N Engl J Med,2010,363(20) : 1938-1948.
  • 3Levine B, Kroemer G. Autophagy in the pathogenesis of disease [ J ]. Cell,2008,132 ( 1 ) :27-42.
  • 4Yu L, McPhee CK, Zheng L, et al. Termination of autophagy and reformation of lysosomes regulated by mTOR [ J ]. Nature, 2010,465 ( 7300 ) :942-946.
  • 5Vanderlaag K, Su Y, Frankel AE, et al. 1 ,1-Bis(3'-indolyl)- 1-(p-substituted phenyl ) methanes induce autophagic cell death in estrogen receptor negative breast cancer [ J ]. BMC Cancer,2010,10:669.
  • 6Bhutia SK, Dash R, Das SK, et al. Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/intedeukin-24 [J]. Cancer Res,2010,70(9 ) :3667-3676.
  • 7Mujumdar N, Saluja AK. Autophagy in pancreatic cancer: an emerging mechanism of cell death[J]. Autophagy,2010,6(7) : 997 -998.
  • 8Li Z, Chen B, Wu Y, et al. Genetic and epigenetic silencing of the beclin 1 gene in sporadic breast tumors [ J ]. BMC Cancer,2010,10:98.
  • 9Liang XH, Jackson S, Seaman M, et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1 [ J ]. Nature, 1999,402 ( 6762 ) :672-676.
  • 10John S, Nayvelt I, Hsu HC, et al. Regulation of estrogenic effects by beclin 1 in breast cancer cells [ J ]. Cancer Res, 2008,68(19) :7855-7863.

共引文献149

同被引文献90

引证文献6

二级引证文献23

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部