摘要
目的探讨化疗联合加味良附丸治疗晚期胃癌的临床疗效及对血清学指标和生活质量的影响。方法回顾性分析58例晚期胃癌患者的临床资料,根据治疗方法的不同将患者分为对照组和观察组,每组29例。对照组患者接受单纯化疗,观察组患者接受化疗联合加味良附丸治疗,比较两组患者的临床疗效、血清学指标及生活质量。结果观察组和对照组患者的总有效率分别为48.28%和31.03%,差异无统计学意义(P﹥0.05)。治疗前,两组患者的血清肿瘤坏死因子-α(TNF-α)、γ-干扰素(IFN-γ)、白细胞介素-12(IL-12)、血管内皮细胞生长因子(VEGF)、基质金属蛋白酶2(MMP2)、基质金属蛋白酶3(MMP3)、环氧化酶-2(COX-2)水平比较,差异均无统计学意义(P﹥0.05)。治疗后,观察组患者的血清TNF-α、IFN-γ、IL-12水平均高于对照组,血清VEGF、MMP2、MMP3、COX-2水平均低于对照组,差异均有统计学意义(P﹤0.05)。治疗前,两组患者躯体功能、角色功能、情绪功能、认知功能、社会功能评分比较,差异均无统计学意义(P﹥0.05)。治疗后,观察组患者的躯体功能、角色功能、情绪功能、认知功能、社会功能评分均明显高于对照组,差异均有统计学意义(P﹤0.01)。结论化疗联合加味良附丸对于晚期胃癌具有一定的治疗效果,可提高血清TNF-α、IFN-γ、IL-12水平,降低血清VEGF、MMP2、MMP3、COX-2水平,提高患者的生活质量。
Objective To analyze the clinical effect of chemotherapy combined with Jiawei Liangfu pills in the treatment for patients with advanced gastric cancer,and investigate the effect on serological markers and quality of life.Method A retrospective analysis including the clinical data of 58 patients with advanced gastric cancer was performed,the subjects were assigned into control group(n=29)or study group(n=29)according to respective therapy administered.The patients in control group were treated with chemotherapy alone,while the study group was treated with combined therapy of chemotherapy and Jiawei Liangfu pills,and then the clinical effect,serological markers and quality of life of the two groups were compared.Result The overall response rate of study group was 48.28%and that of control group was 31.03%,with no significant difference observed(P >0.05).Before treatment,there was no significant difference regarding the level of tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),interleukin-12(IL-12),vascular endothelial growth factor(VEGF),matrix metalloproteinase 2(MMP2),matrix metalloproteinase 3(MMP3),cyclooxygenase-2(COX-2)between the two groups(P >0.05).After treatment,the TNF-α,IFN-γand IL-12 level were significantly higher in study group than those in control group(P<0.05),while the level of VEGF,MMP2,MMP3,and COX-2 were lower than those in control group(P<0.05).Before treatment,the scores of physical function,role function,emotional function,cognitive function and social function in both groups were similar(P >0.05);but all were significantly higher in study group compared with those in control group after treatment(P<0.01).Conclusion The combined therapy of chemotherapy and Jiawei Liangfu pills is fairly effective in the treatment for advanced gastric cancer,by improving the level of TNF-α,IFN-γ,and IL-12,while reducing the level of VEGF,MMP2,MMP3,and COX-2,and therefore may ameliorate the quality of life for these patients.
作者
赵航
戴玮
ZHAO Hang;DAI Wei(Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,jiangsu,China)
出处
《癌症进展》
2019年第2期194-197,共4页
Oncology Progress
关键词
加味良附丸
晚期胃癌
生活质量
免疫
疗效
Jiawei Liangfu pill
advanced gastric cancer
quality of life
immunization
therapeutic effect
