摘要
目的:利用正交试验减少静脉用药集中调配中心(PIVAS)难溶性抗菌药物的残留量。方法:选定溶媒类型、溶媒体积和溶药针类型三个因素,每个因素确定两个水平,即溶媒类型为0. 9%氯化钠注射液和灭菌注射用水,溶媒体积为5 m L和8 m L,溶药针类型为直孔溶药针和侧孔溶药针,进行三因素两水平的正交试验,考察各个因素对难溶性抗菌药物残留体积和残留量的影响。结果:影响PIVAS难溶性抗菌药物残留体积的主要因素为溶药针类型,其次为溶媒体积、溶媒类型;影响残留量的主要因素为溶媒体积,其次为溶药针类型,溶媒类型最小。结论:选择适宜溶媒类型、溶媒体积和溶药针类型调配难溶性抗菌药物,可降低西林瓶内的残留量,提高成品输液质量。
Objective:To reduce the residue of dissolved antibiotics by orthogonal design in pharmacy intravenous admixture service.Methods:Three factors were selected including solvent type,solvent volume and solvent needle type.Each factor determined two levels,namely,the solvent type was 0.9%sodium chloride injection and sterile water for injection,the solvent volume was 5 mL and 8 mL,and the solvent needle type was straight-hole needles and side-hole needles.Three-factor and two-level orthogonal design were carried out to investigate the effects of various factors on the residual volume and residual amount of dissolved antibiotics in pharmacy intravenous admixture service.Results:The main factors affecting the residual volume of dissolved antibiotics in pharmacy intravenous admixture service were the largest solvent needle type,the second in solvent volume,and the smallest in solvent type.The main factors affecting the residual amount were the largest solvent volume,followed by solvent needle type and solvent type.Conclusion:Appropriate selection of solvent type,solvent volume and solvent needle type in preparing dissolved antibiotics can reduce the residue in the bottle and improve the quality of finished infusion quality.
作者
齐雷
高婕
吕昌亮
吕飞飞
Qi Lei;Gao Jie;Lyu Changliang;Lyu Feifei(Central Hospital of Zibo,Shandong Zibo 255000,China)
出处
《儿科药学杂志》
CAS
2019年第2期49-51,共3页
Journal of Pediatric Pharmacy
关键词
静脉用集中药调配中心
难溶性抗菌药物
正交试验
残留
pharmacy intravenous admixture service
dissolved antibiotics
orthogonal design
residue
