摘要
目的:探讨血清细胞质胸苷激酶1(TK1)在非小细胞肺癌(NSCLC)辅助诊断方面的临床应用价值。方法:运用免疫增强化学发光法(ECL)检测比较106例NSCLC患者、36例良性肺疾病患者和50例健康体检者的TK1水平,分析TK1单独及联合传统肿瘤标志物(CEA、NSE、CYFRA21-1和SCC-Ag)检测在非小细胞肺癌辅助诊断中的价值;并进一步分析TK1与NSCLC患者临床病理参数间的相关性。结果:NSCLC组患者TK1水平及阳性率显著高于良性肺疾病组和健康对照组(P <0. 05),而良性肺疾病组与健康对照组之间TK1水平差异无统计学意义(P> 0. 05); NSCLC患者TK1水平与性别、年龄、吸烟史和淋巴结转移状态无显著相关性;与患者的病理类型、分化程度、TNM分期和远处转移情况密切相关;各项肿瘤指标单独检测时,敏感性都不高,而五项联合检测则可将NSCLC的敏感性和准确性显著提高。结论:血清TK1作为一种新的肿瘤标志物,在肺癌的辅助诊断中具有潜在的应用价值。
Thread embolism,Focal cerebralObjective:To explore the clinical value of serum cytoplasmic thymidine kinase 1(TK1)in the diagnosis of non-small cell lung cancer(NSCLC).Methods:Immunohistochemical chemiluminescence(ECL)was used to detect and compare the TK1 levels in 106 NSCLC patients,36 benign lung disease patients,and 50 healthy subjects.Analyze the value of TK1 alone or in combination with traditional tumor markers(CEA,NSE,CYFRA21-1,and SCC-Ag)in the diagnosis of non-small cell lung cancer.And then study the correlation between TK1 level and clinicopathological features of NSCLC patients.Results:The level of TK1 and positive rate in NSCLC group were significantly higher than those in benign lung disease group and healthy control group(P﹤0.05),but there was no significant difference in TK1 level between benign lung disease group and healthy control group(P﹥0.05).There was no significant correlation between TK1 level and gender,age,smoking history and lymph node metastasis status in NSCLC patients;but it was closely related to the pathological type,differentiation degree,TNM stage and distant metastasis.Conclusion:As a new tumor marker,serum TK1 has potential application value in the auxiliary diagnosis of lung cancer.ischemia in rats,Influencing factors,External environment temperature
作者
韩卫卫
朱明
狄冬梅
HAN Weiwei;ZHU Ming;Di Dongmei(Department of Thoracic Surgery,Changzhou Tumor Hospital Affiliated with Soochow University,Changzhou City,Jiangsu Province 213000)
出处
《医学理论与实践》
2019年第3期319-321,共3页
The Journal of Medical Theory and Practice
关键词
胸苷激酶1
非小细胞肺癌
辅助诊断
Serum thymidine kinase 1
Non-small cell lung cancer
Assisted diagnosis
