摘要
目的观察前列腺MR扩散加权成像(DWI)检查中表观弥撒系数(ADC)定量预测前列腺癌(PCa)根治术预后的临床价值。方法前瞻性纳入2014年5月至2016年5月收治的行前列腺癌根治术的82例前列腺癌患者为对象。检测并统计两组不同弥撒敏感系数b值600 s/mm^2和1 000 s/mm^2下前列腺中央带组织及外周带的ADC值变化,持续随访1年,观察并统计患者远期预后。结果 82例PCa患者中外周带52例,中央带28例,中央带与外周带同时累及2例,DWI上呈高(或稍高)信号,ADC图上呈低(或稍低)信号。82例患者出院后1年无事件生存62例,占75. 61%;死亡20例,占24. 39%。当b值取600 s/mm^2及1 000 s/mm^2时,死亡组前列腺中央带组织及外周带的ADC值均显著低于生存组(P <0. 05)。不同b值下前列腺磁共振弥散ADC值对不良预后均有一定预测价值,于前列腺中央带组织,b值取600 s/mm^2及1 000 s/mm^2时,曲线下面积分别为0. 809、0. 813;于前列腺癌外周带组织,b值取600 s/mm^2及1 000 s/mm^2时,曲线下面积分别为0. 815、0. 896。结论前列腺DWI检查中ADC值可以预测前列腺癌的生物学特性,对预测前列腺癌根治术后患者远期不良预后具有重要临床意义。
Objective To investigate the prognostic value of apparent diffusion coefficient(ADC)in prostate MR diffusion weighted imaging(DWI)in predicting the prognosis of radical prostatectomy for prostate cancer(PCa).Methods From May 2014 to May 2016,82 patients with prostate cancer who underwent radical prostatectomy in our hospital were selected as the subjects.The ADC values of the central tissue and peripheral zone of the prostate were detected and counted under different b values in 2 groups.The patients were followed up for 1 year,and the long-term prognosis of the patients was observed and counted.Results 62 of 82 patients survived 1 year after discharge,accounting for 75.61%;20 cases died,accounting for 24.39%.When the b value was 600 s/mm^2 and 1000 s/mm^2,the ADC values of the central tissue and peripheral zone of the prostate in the death group were significantly lower than those in the survival group(P<0.05).Under different b values of prostate MRI diffusion weighted ADC value on prognosis has certain predictive value in the central zone of prostate tissue,b values of 600 s/mm^2 and 1000 s/mm^2,the area under the curve were 0.809 and 0.813;in the peripheral zone of prostate cancer tissue,b values of 600 s/mm^2 and 1000 s/mm^2,the area under the curve was 0.815,respectively 0.896.Conclusion The ADC value in prostate DWI examination can predict the biological characteristics of prostate cancer,and has important clinical significance in predicting the long-term adverse prognosis of patients after radical prostatectomy.
作者
崔俐莉
刘进康
CUI Li-li;LIU Jin-kang(Department of Radiology,Xiangya Hospital Central South University,Changsha Hunan 410008,China)
出处
《临床和实验医学杂志》
2019年第3期327-330,共4页
Journal of Clinical and Experimental Medicine
