摘要
Chronic inflammation is known to contribute to human tumorigenesis,with an estimated 20%of adult cancers being attributable to chronic inflammatory conditions caused by infectious agents as well as chronic noninfectious inflammatory diseases.Recently,chronic inflammation is regarded as an‘enabling characteristic’of human cancer.In addition,the impact of chronic inflammation is also noticed on the outcome of cancer therapy and design of new therapeutic approaches.Nutrients are necessary for maintaining general health,and most of researches have focused on their beneficial effects on immune functions.However,the effects of nutrition in regulating inflammation deserve a close attention.Naturally,the nutrition-decreased inflammation reduces the risk of cancer in healthy individuals and normalizes the physical state of cancer patients.Therefore,it is valuable to understand the cellular nutrition in modulating inflammation.In the present review,I will summarize the impacts of inflammation on tumorigenesis and discuss the benefits of nutrition in regulating inflammation and the underlying mechanisms.It is believed that nutritional approaches to regulating inflammation will open a new window for cancer prevention and therapy.
