摘要
目的通过超声观察接受控制性促排卵方案(control ovarian stimulation,COS)助孕患者子宫内膜容受性及卵巢内卵泡储备影像学特点,分析超声评估对不孕患者妊娠结局的预测作用。方法回顾性分析接受COS治疗的不孕症患者209周期的相关资料。根据妊娠结局分为妊娠组(30周期)和未妊娠组(未妊娠者中随机选取30周期),比较2组子宫内膜厚度、子宫内膜类型、子宫内膜容积、卵巢体积、窦卵泡数以及排卵前最大卵泡直径。根据内膜厚度分为<8mm、8～14mm、>14mm组,根据内膜类型分为A型、B型、C型组,根据内膜容积分为<2mL、2～4mL、>4mL,根据卵巢体积分为<3cm3、3～6cm3、>6cm3,根据窦卵泡数分为<5个、5～15个、>15个,比较各组妊娠率。结果妊娠组子宫内膜厚度和内膜容积均大于未妊娠组,妊娠组子宫内膜形态A型较多,未妊娠组子宫内膜形态C型较多,妊娠组卵巢体积、窦卵泡数明显大于或多于未妊娠组,差异有统计学意义(P<0.05);2组人绒毛膜促性腺激素日最大卵泡直径差异无统计学意义(P>0.05)。子宫内膜厚度8～14mm组妊娠率明显高于<8mm、>14mm组,子宫内膜A型组妊娠率明显高于B型、C型组,子宫内膜容积>4mL组妊娠率明显高于<2mL、2～4mL组,卵巢体积3～6cm3组妊娠率明显高于<3cm3、>6cm3组,卵泡数5～15个组妊娠率明显高于<5个、>15个组,差异均有统计学意义(P<0.05)。结论对于接受COS治疗的不孕患者,超声监测子宫内膜厚度8～14mm、子宫内膜容积>4mL、子宫内膜类型A型、卵巢体积3～6cm3、窦卵泡数5～15个时妊娠的概率更大。
Objective To analyze the predictive effect of ultrasonography on pregnancy outcomes of infertile women by observing the intraovarian follicle reserve imaging characteristics and endometrial receptivity of infertile women receiving controlled ovarian stimulation(COS)via ultrasonography.Methods Retrospective analysis the related data of 209 cycles were taken from infertile patients treated with COS.According to the pregnancy outcome,the cycles were divided into the pregnancy group(30 cycles)and the non-pregnant group(30 cycles randomly selected from the non-pregnant patients).The endometrial thickness,endometrial type,endometrial volume,ovarian volume,number of antral follicles and the maximum diameter of follicles before ovulation of both groups were compared.The 60 cycles were divided into group<8 mm,group 8-14 mm,and group >14 mm,according to the endometrial thickness;type A,type B,and type C,according to the endometrial type;group<2 mL group 2-4 mL and group >4 mL,according to the endometrial volume;group<3 cm 3,group 3-6 cm 3,and group >6 cm 3,according to the ovarian volume;group<5,group 6-15 and group >15,according to the number of antral follicles.The pregnancy rates of each group were compared.Results The endometrial thickness and endometrial volume of the pregnant group were higher than those of the non-pregnant group.In the pregnant group,the endometrial morphology type A was in the majority,while in the non-pregnant group,the endometrial morphology type C was in the majority;the ovarian volume and the number of antral follicles in the pregnant group were significantly higher than those of the non-pregnant group,the differences above were statistically significant(P<0.05).There was no significant difference in the maximum follicle diameter on the day of human chorionic gonadotropin injection between the two groups(P >0.05).The pregnancy rate of the endometrial thickness 8-14 mm group was significantly higher than that of the group<8 mm and group >14 mm;the pregnancy rate of endometrial type A group was significantly higher than that of type B and type C;the pregnancy rate of endometrial volume >4 mL group was significantly higher than that of group<2 mL and group 2-4 mL;the pregnancy rate of ovarian volume 3-6 cm 3 group was significantly higher than that of group<3 cm 3 and group >6 cm 3,and the pregnancy rate of 5-15 follicles group was significantly higher than that of group<5 and group >15,the differences above were statistically significant(P<0.05).Conclusion For infertility patients receiving COS treatment,the ones with endometrial thickness between 8-14 mm,endometrial volume greater than 4 ml,endometrium type A,ovaria volume between 3-6 cm 3 and the number of antral follicles between 5-15 are more likely to get pregnant.
作者
张志峰
赵双丹
曹明雅
崔晓莉
贾蕊
赵志明
ZHANG Zhi-feng;ZHAO Shuang-dan;CAO Ming-ya;CUI Xiao-li;JIA Rui;ZHAO Zhi-ming(Department of Function,Pingxiang General Hospital,Hebei Province,Pingxiang 054500,China;Department of Reproductive Medicine,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China)
出处
《河北医科大学学报》
CAS
2019年第3期324-328,共5页
Journal of Hebei Medical University
关键词
不育
女(雌)性
妊娠结局
排卵诱导
超声检查
infertility,female
pregnancy outcome
ovulation induction
ultrasonography
