期刊文献+

Aphasia rehabilitation based on mirror neuron theory: a randomized-block-design study of neuropsychology and functional magnetic resonance imaging 被引量:30

Aphasia rehabilitation based on mirror neuron theory: a randomized-block-design study of neuropsychology and functional magnetic resonance imaging
下载PDF
导出
摘要 When watching someone performs an action, mirror neurons are activated in a way that is very similar to the activation that occurs when actually performing that action. Previous single-sample case studies indicate that hand-action observation training may lead to activation and remodeling of mirror neuron systems, which include important language centers, and may improve language function in aphasia patients. In this randomized-block-design experiment, we recruited 24 aphasia patients from, Zhongda Hospital, Southeast University, China. The patients were divided into three groups where they underwent hand-action observation and repetition, dynamic-object observation and repetition, or conventional speech therapy. Training took place 5 days per week, 35 minutes per day, for 2 weeks. We assessed language function via picture naming tests for objects and actions and the Western Aphasia Battery. Among the participants, one patient, his wife and four healthy student volunteers underwent functional magnetic resonance imaging to analyze changes in brain activation during hand-action observation and dynamic-object observation. Results demonstrated that, compared with dynamic-object observation, hand-action observation led to greater performance with respect to the aphasia quotient and affiliated naming sub-tests and a greater Western Aphasia Battery test score. The overall effect was similar to that of conventional aphasia training, yet hand-action observation had advantages compared with conventional training in terms of vocabulary extraction and spontaneous speech. Thus, hand-action observation appears to more strongly activate the mirror neuron system compared with dynamic-object observation. The activated areas included Broca's area, Wernicke's area, and the supramarginal gyrus. These results suggest that hand-action observation combined with repetition might better improve language function in aphasia patients compared with dynamic-object observation combined with repetition. The therapeutic mechanism of this intervention may be associated with activation of additional mirror neuron systems, and may have implications for the possible repair and remodeling of damaged nerve networks. The study protocol was approved by the Ethical Committee of Nanjing Medical University, China(approval number: 2011-SRFA-086) on March 11, 2011. This trial has been registered in the ISRCTN Registry(ISRCTN84827527). When watching someone performs an action, mirror neurons are activated in a way that is very similar to the activation that occurs when actually performing that action. Previous single-sample case studies indicate that hand-action observation training may lead to activation and remodeling of mirror neuron systems, which include important language centers, and may improve language function in aphasia patients. In this randomized-block-design experiment, we recruited 24 aphasia patients from, Zhongda Hospital, Southeast University, China. The patients were divided into three groups where they underwent hand-action observation and repetition, dynamic-object observation and repetition, or conventional speech therapy. Training took place 5 days per week, 35 minutes per day, for 2 weeks. We assessed language function via picture naming tests for objects and actions and the Western Aphasia Battery. Among the participants, one patient, his wife and four healthy student volunteers underwent functional magnetic resonance imaging to analyze changes in brain activation during hand-action observation and dynamic-object observation. Results demonstrated that, compared with dynamic-object observation, hand-action observation led to greater performance with respect to the aphasia quotient and affiliated naming sub-tests and a greater Western Aphasia Battery test score. The overall effect was similar to that of conventional aphasia training, yet hand-action observation had advantages compared with conventional training in terms of vocabulary extraction and spontaneous speech. Thus, hand-action observation appears to more strongly activate the mirror neuron system compared with dynamic-object observation. The activated areas included Broca's area, Wernicke's area, and the supramarginal gyrus. These results suggest that hand-action observation combined with repetition might better improve language function in aphasia patients compared with dynamic-object observation combined with repetition. The therapeutic mechanism of this intervention may be associated with activation of additional mirror neuron systems, and may have implications for the possible repair and remodeling of damaged nerve networks. The study protocol was approved by the Ethical Committee of Nanjing Medical University, China(approval number: 2011-SRFA-086) on March 11, 2011. This trial has been registered in the ISRCTN Registry(ISRCTN84827527).
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第6期1004-1012,共9页 中国神经再生研究(英文版)
基金 supported by the National Natural Science Foundation of China,No.81472163,81874035(to CLS) the General Project of University Philosophy and Social Science Research of China,No.2016SJB740015(to QY) the Science and Technology Plan Project of Zhangjiagang city of China in 2016,No.ZKS1615(to WLC) the Youth Science and Technology Project of Suzhou Health Development through Scientific Research and Education in 2018,No.KJXW2018059(to WLC)
关键词 NERVE REGENERATION mirror neuron hand-action observation APHASIA REHABILITATION stroke functional magnetic resonance imaging NEUROPSYCHOLOGY neural REGENERATION nerve regeneration mirror neuron hand-action observation aphasia rehabilitation stroke functional magnetic resonance imaging neuropsychology neural regeneration
  • 相关文献

参考文献4

二级参考文献75

  • 1AAN (1994) Assessment: melodic intonation therapy. Neurology 44:566- 568.
  • 2Anglade C, Thiel A, Ansaldo AI (2014) The complementary role of the ce- rebral hemispheres in recovery from aphasia after stroke: a critical review of literature. Brain Inj 28:138-145.
  • 3Ashtary F, Janghorbani M, Chitsaz A, Reisi M, Bahrami A (2006) A random- ized, double-blind trial of bromocriptine efficacy in nonfluent aphasia after stroke. Neurology 66:914-916.
  • 4Baker JM, Rorden C, Fridriksson J (2010) Using transcranial direct-current stimulation to treat stroke patients with aphasia. Stroke 41:1229-1236.
  • 5Barwood CH, Murdoch BE, Whelan B-M, Lloyd D, Riek S, O'Sullivan J, Coulthard A, Wong A, Aitken P, Hall G (2011) The effects of low fre- quency Repetitive Transcranial Magnetic Stimulation (rTMS) and sham condition rTMS on behavioural language in chronic non-fluent aphasia: Short term outcomes. NeuroRehabilitation 28:113-128.
  • 6Beeson PM, Robey RR (2006) Evaluating single-subject treatment research: lessons learned from the aphasia literature. Neuropsychol Rev 16:161- 169.
  • 7Berthier ML (2014) Cognitive enhancing drugs in aphasia: A vote for hope. Aphasiology 28:128-132.
  • 8Berthier ML, Pulverm/iller E Divila G, Casares NG, Guti6rrez A (2011) Drug therapy of post-stroke aphasia: a review of current evidence. Neu- ropsychol Rev 21:302-317.
  • 9Berthier ML, Green C, Higueras C, Fernandez I, Hinojosa l, Martin M (2006) A randomized, placebo-controlled study of donepezil in poststroke apha- sia. Neurology 67:1687-1689.
  • 10Berthier ML, Green C, Lara JP, Higueras C, Barbancho MA, Divila G, Pul- vermiller F (2009) Memantine and constraint-induced aphasia therapy in chronic poststroke aphasia. Ann Neuro165:577-585.

共引文献211

同被引文献256

引证文献30

二级引证文献139

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部