摘要
目的探讨凝血指标、炎症因子和糖类抗原125(CA125)在子宫内膜异位症(简称内异症)诊断与分期中的应用价值。方法选取150例内异症患者纳入内异症组,另选取100例良性卵巢囊肿患者纳入对照组。比较2组患者血浆凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)、D-二聚体(D-D)、中性粒细胞计数/淋巴细胞计数(NLR)、血小板计数/淋巴细胞计数(PLR)、白介素-6(IL-6)和CA125水平;将内异症组患者按临床分期分为Ⅰ～Ⅱ期组与Ⅲ～Ⅳ期组,比较两者上述指标的差异;评估血液指标与临床分期之间的相关性,并绘制受试者工作特征(ROC)曲线,评价相关指标在内异症诊断中的价值。结果内异症组患者血浆PT、TT显著短于对照组(P<0.01),FIB、D-D、NLR、PLR、IL-6和CA125水平均显著高于对照组(P<0.01);Ⅲ～Ⅳ期组患者FIB、IL-6和CA125水平均显著高于Ⅰ～Ⅱ期组(P<0.01)。内异症组患者FIB、IL-6和CA125水平与内异症临床分期呈显著正相关(P<0.01),FIB、IL-6、CA125联合检测的灵敏度高于单独检测,但特异度与单独检测相似。结论内异症患者体内存在血液高凝状态,FIB、IL-6和CA125水平与内异症病情严重程度呈显著正相关,与单独检测比较,3项指标联合检测在内异症的诊断中具有更高的临床应用价值。
Objective To explore value of coagulation indicators,inflammatory factors and glycoantigen 125(CA125)in diagnosis of endometriosis and its clinical staging.Methods A total of 150 patients with endometriosis were enrolled in endometriosis group,while 100 patients with benign ovarian cyst were enrolled in control group.The prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),fibrinogen(FIB),D-Dimer(D-D),neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),interleukin-6(IL-6)and CA125 between two groups were compared.The patients in endometriosis group were divided intoⅠ~Ⅱstage group andⅢ~Ⅳstage group according to clinical staging,and the above indicators were observed.The correlation between blood indicators and clinical staging was evaluated,while the application value of related indicators in diagnosis of endometriosis was evaluated by drawing receiver operating characteristic curve(ROC).Results The levels of PT and TT in endometriosis group were obviously shorter than that in control group(P<0.01),while the levels of FIB,D-D,NLR,PLR,IL-6 and CA125 in endometriosis group were obviously higher than that in control group(P<0.01).The levels of FIB,IL-6 and CA125 inⅢ-Ⅳstage group were obviously higher than that inⅠ~Ⅱstage group(P<0.01).The levels of FIB,IL-6 and CA125 were positively correlated with clinical staging(P<0.01).The sensitivity of combined detection of FIB,IL-6 and CA125 was higher than that of detection alone,while the specificity was similar.Conclusion Hypercoagulable state may exist in patients with endometriosis.The levels of FIB,IL-6 and CA125 were positively correlated with severity of illness.Compared with detection alone,the combined detection may have higher value in diagnosis of endometriosis.
作者
曹月婷
刘贵朋
GAO Yueting;LIU Guipeng(Department of Obstetrics and Gynecology,Shengjing Hospital Affiliated to China Medical University,Shenyang,Liaoning,110001)
出处
《实用临床医药杂志》
CAS
2019年第3期88-92,共5页
Journal of Clinical Medicine in Practice
