摘要
目的:观察扶正抗癌饮经验方防治成人急性髓系白血病化疗后骨髓抑制的临床效果。方法:选取2014年1月至2017年1月成都中医药大学附属医院收治的成人急性髓系白血病化疗后患者116例,按照随机数字表法随机分为对照组和观察组,每组58例,对照组采用标准DA方案诱导化疗;观察组在对照组基础上于化疗后加用自拟扶正抗癌饮经验方治疗。2组均以3周为1个周期,连续治疗3个周期。记录骨髓抑制的发生时间、恢复时间,统计骨髓抑制发生率,评价其发生程度,监测化疗后外周血象变化,评价治疗前后的生命质量,比较化疗后的不良反应。结果:观察组骨髓抑制的发生时间明显晚于对照组,而骨髓抑制恢复时间明显早于对照组(P <0. 05);观察组骨髓抑制发生率为17. 2%,明显低于对照组的48. 3%(P <0. 05);化疗后观察组WBC、PLT、Hb含量较对照组显著升高(P <0. 05);观察组其生命质量评分显著高于对照组(P <0. 05);观察组不良反应发生率为15. 5%,显著低于对照组的37. 9%(P <0. 05)。结论:扶正抗癌饮经验方有助于延缓骨髓抑制的发生时间,促进骨髓抑制的恢复,降低化疗后骨髓抑制发生率,减轻骨髓抑制的严重程度,提高生命质量,减少化疗后的不良反应,有一定的临床推广应用价值。
Objective:To study the clinical effects of Fuzheng Kangai Decoction on the prevention and treatment of bone marrow suppression in adult acute myeloid leukemia after chemotherapy.Methods:A total of 116 patients in Affiliated Hospital of Chengdu University of Traditional Chinese Medicine from January 2014 to January 2017 were randomly divided into a control group observation group with 58 cases in each group.The patients in control group received standard of DA induction chemotherapy,while the patients in the observation group were treated with Fuzheng Kangai Decoction after the chemotherapy on the basis of the control group,with 3 weeks for a cycle,3 cycles for treatment.The occurrence time and recovery time of BMD(bone mineral density)were recorded,the incidence rate of BMD was counted,the degree of occurrence was evaluated,the changes in peripheral blood images after chemotherapy were monitored,the quality of life before and after treatment was evaluated,and the toxic and side effects after chemotherapy were compared.Results:Observation group of bone marrow suppression occurring time was more later than that of the control group,and bone marrow suppression recovery time was earlier than that of the control group(P<0.05).Bone marrow inhibition rate of observation group was 17.2%,which was significantly lower than that of the control group of 48.3%(P<0.05).After chemotherapy,the WBC,Hb and PLT levels were significantly higher than that of the control group(P<0.05).The quality of life was better than that of control group,the quality of life score was significantly higher than the control group(P<0.05).The incidence of adverse reactions of infection and hemorrhage of the observation group was 15.5%,which was significantly lower than that of the control group of 37.9%(P<0.05).Conclusion:Fuzheng Kangai Decoction obviously delay the time of the occurrence of bone marrow suppression,promote the recovery of bone marrow suppression,reduce the degree of bone marrow suppression,reduce the severity of the bone marrow suppression,improve the quality of life,and reduce the incidence of adverse reactions,which is worth clinical promotion.
作者
杨玉婷
赵梓亦
辜海英
王钧冬
林俊芝
Yang Yuting;Zhao Ziyi;Gu Haiying;Wang Jundong;Lin Junzhi(Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China)
出处
《世界中医药》
CAS
2019年第2期430-433,共4页
World Chinese Medicine
基金
成都市科技惠民技术研发项目(2015-HM01-00461-SF)
关键词
急性髓系白血病
骨髓抑制
化疗后
成人
扶正抗癌饮经验方
Acute myeloid leukemia
Bone marrow suppression
After chemotherapy
Fuzheng Kangai Decoction
