摘要
腺苷酸环化酶(adenyl cyclase,AC)是G蛋白偶联受体(G protein-coupled receptor,GPCR)下游的关键信号分子,通过调节环腺苷-3',5'-一磷酸(c AMP)的合成调控多种细胞功能,从而参与机体的多种病理生理过程。哺乳动物细胞表达了9个跨膜AC亚型(AC1～9,mACs)和1个可溶性AC(sAC,也称为AC10),各亚型在不同组织细胞膜微筏(脂筏)中存在差异性表达,由于不同亚型间具有非特异的交叉协同性或拮抗性,各亚型的非选择性激活/抑制会带来很多潜在的不良反应,因此目前还缺乏特异性的激动剂和抑制剂。认识和了解AC各亚型的研究现状,对进一步研究各亚型特异性激动剂/抑制剂及未来靶向药物的研究具有重要意义。
Adenyl cyclase(AC),as a key downstream signaling factor of G protein-coupled receptor(GPCR),is involved in a variety of potential physiological and pathological processes by adjusting the cyclic adenosine-3',5'-monophosphate(cAMP).So far,nine membrane isoforms(AC1-9)and a soluble adenyl cyclase(sAC)have been cloned.They are expressed in different organs,and have different physiological functions.Non-selective activation/inhibition has many potential side effects.In this article we will summarize the current research of AC isoforms.Research on specific agonists/inhibitors and potential targeted drugs is of great significance.
作者
杨琰茗
杨雅清
宋杲
杨为民
翁稚颖
YANG Yanming;YANG Yaqing;SONG Gao;YANG Weimin;WENG Zhiying(School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products,Kunming Medical University,Kunming 650500,China)
出处
《临床与病理杂志》
2019年第2期390-394,共5页
Journal of Clinical and Pathological Research
基金
国家自然科学基金(81860012)
云南省科学基金(2017FE467-023)
滇美分子药物联合研究中心(2015ID001)~~
