摘要
目的:检测尖锐湿疣皮损中M1/M2型巨噬细胞的表达。方法:采用免疫组织化学SP法检测30例尖锐湿疣皮损组织及15例正常组织中诱导型一氧化氮合酶(iNOS)标记的M1型巨噬细胞和CD163标记的M2型巨噬细胞的表达。结果:尖锐湿疣皮损组织中iNOS+M1型巨噬细胞的浸润数量为(6.16±3.32)/HP与正常组织(6.76±0.87)/HP比较,无统计学差异(P>0.05)。CD163+M2巨噬细胞的浸润数量(22.30±6.27)/HP高于正常组织(9.81±4.23)/HP,差异有统计学意义(P<0.05)。iNOS+M1型和CD163+M2型巨噬细胞在CA组织中的浸润呈负相关(P<0.05)。结论:尖锐湿疣皮损中浸润的巨噬细胞以M2型为主,可能在尖锐湿疣逃避机体免疫反应中发挥重要作用。
Objective:To detect the expression of M1/M2 macrophages in the lessions of condyloma acuminatum(CA).Methods:The expression of iNOS-labeled M1 macrophages and CD163-labeled M2 macrophages were detected by immunohistochemistry streptavidin-peroxidase methodin in CA lesions of 30 patients and15 normal controls.Results:The number of iNOS+M1 macrophage in CA lesions and normal tissues was(6.16±3.32)/HP and(6.76±0.87)/HP,with no significant difference(P>0.05).The number of CD163+M2 macrophages in CA lesions and normal tissue was(22.30±6.27)/HP and(9.81±4.23)/HP,with a significant difference(P<0.05).There was a negative correlation between the level of iNOS+M1 and CD163+M2 macrophages in CA lesions(P<0.05).Conclusion:Macrophages infiltration in CA lesions mainly are M2,which may play an important role in CA escaping immune responses.
作者
刘睿
孙弦
胡珍
吴庭
曹育春
彭才智
LIU Rui;SUN Xian;HU Zhen;WU Ting;CAO Yuchun;PENG Caizhi(Department of Dermatology,Wuhan Third Hospital,Wuhan 430070,China;Department of Dermatology,Tongji Hospital,Tongji Medical College,Huazhong University of science and Technology,Wuhan 430000,China)
出处
《中国麻风皮肤病杂志》
2019年第2期80-82,共3页
China Journal of Leprosy and Skin Diseases
