摘要
非酒精性脂肪性肝病(NAFLD)主要包括单纯性脂肪肝(NAFL)、非酒精性脂肪性肝炎(NASH)、相关肝硬化和肝细胞癌。相对于NAFL,NASH更易发展为肝硬化和肝癌,故早期诊断并对其干预尤为重要。近年来,多项无创诊断方法的出现致力于替代肝脏穿刺活检,主要包括血清学和影像学检查等,本文就无创性诊断和评估NASH作一综述。
Nonalcoholic fatty liver disease (NAFLD) includes a spectrum of diseases ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH),cirrhosis and eventually to hepatocellular carcinoma (HCC). NASH has an increased risk for advanced cirrhosis and HCC,so there has been an urgent need to accurately distinguish between NAFL and NASH and intervene its further development in early time. In recent years,many noninvasive diagnostic methods including serological markers and imaging examination were applied in clinical practice trying to replace liver biopsy. This article reviews the noninvasive diagnosis and evaluation of NASH.
作者
谢晓
陆伦根
Xie Xiao;Lu Lungen(Department of Gastroenterology,Shanghai General Hospital,JiaoTong University School of Medicine,Shanghai 200080)
出处
《实用肝脏病杂志》
CAS
2019年第2期301-304,共4页
Journal of Practical Hepatology
基金
国家自然科学基金面上项目(编号:81670548)
关键词
非酒精性脂肪性肝病
非酒精性脂肪性肝炎
无创诊断
评估
Nonalcoholic fatty liver disease
Nonalcoholic steatohepatitis
Noninvasive diagnosis
Assessment
