摘要
目的探讨功能性消化不良(functional dyspepsia,FD)与代谢综合征(metabolic syndrome,MS)及其组分的关系。方法本研究选取2015～2017年于笔者医院参加健康体检人群1000例作为研究对象。用单纯随机抽样方法,采用罗马Ⅲ诊断标准筛查功能性消化不良患者,将入组人群分为观察组和对照组,在对筛查人群进行问卷调查,结合生物化学、腹部超声检查等相关资料,分析功能性消化不良人群及正常人群中代谢异常情况,比较两者出现代谢异常的差异。采用秩和检验、单因素和多因素Logistic回归分析对MS与FD进行相关性分析。结果对照组和观察组中非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)检出率分别为16.3%、27.1%,两者检出率比较,差异有统计学意义(P<0.01),对照组和观察组体重指数(body mass index,BMI)、甘油三酯、总胆固醇、血糖、血压比较,差异有统计学意义(P<0.05),多因素回归分析,甘油三酯、脂肪肝、血糖、血压为FD最具可能性的危险因素。结论 FD的发生与甘油三酯、脂肪肝、血糖、血压有密切关系,MS对FD发生有重要影响。
Objective To study the association between metabolic syndrome(MS)with its components and functional dyspepsia(FD).Methods A total of 1000 patients were selected as observed subject from Qinzhou in 2015~2017 health physical examination.Using simple random sampling method,they were average divided into the control group and the observation group according to RomeⅢcriteria.The screened patients underwent a questionnaire survey,biochemical tests and abdominal ultrasound to investigate the metabolic abnormalities of the two groups,and to analyze the relative risk of the metabolic syndrome and its components in the pathogenesis of FD.Univariate and multivariate analyses were performed to analyze the risk factors for FD.Results The detection rate of nonalcoholic fatty liver disease(NAFLD)was 16.3%in control group and 27.1%in observation group,and there was a significant difference between the two groups(P<0.01).Body mass index(BMI),triglyceride,total cholesterol,blood glucose and blood pressure in observation group were higher than those in the control group.There was a significant difference between the two groups(P<0.05).NAFLD,triglyceride,blood glucose and blood pressure might serve as the most important risk factors for FD.Conclusion FD is related to NAFLD,triglyceride,blood glucose and blood pressure.MS has a great effect on FD.
作者
宁琳
韦良宏
陈海东
韦良鹏
苏东兴
劳雪莲
Ning Lin;Wei Lianghong;Chen Haidong(Gastroenterology Department,The First People′s Hospital of Qinzhou,Guangxi 53500,China)
出处
《医学研究杂志》
2019年第1期122-126,共5页
Journal of Medical Research
基金
广西医科大学青年科学基金资助项目(GXMUYSF2014053)
