摘要
目的研究丘脑底核脑深部电刺激术(SNDBS)辅助治疗帕金森病(PD)的临床效果。方法选择2017年2月～2018年4月在广州医科大学附属第一医院治疗的PD患者91例进行研究。根据随机数字表法将患者分成观察组(46例)和对照组(45例),两组患者均常规予以叩背吸痰和吸氧雾化,以及营养支持等措施治疗。对照组另服用多巴丝肼片,观察组在对照组基础上给予SNDBS术式治疗。治疗3个月后比较两组疗效及不良反应,比较两组治疗前及治疗3个月后统一帕金森病评分量表(UPDRS)评分、生活质量评分、尿酸(UA)和丙二醛(MDA)水平。结果观察组总有效率高于对照组(P <0.05)。治疗后,两组UPDRS评分均低于治疗前,且观察组低于对照组;两组生活质量评分高于治疗前,且观察组高于对照组,差异均有统计学意义(P <0.05);两组UA和MDA水平低于治疗前,且观察组低于对照组,差异有统计学意义(P <0.05)。两组不良反应总发生率比较,差异无统计学意义(P> 0.05)。结论应用SNDBS术式辅助治疗PD患者的效果较好,可改善患者的症状及生活质量,并降低氧化应激水平。
Objective To study the clinical effect of subthalamic nucleus deep brain stimulation(SNDBS)in the adjunctive treatment of Parkinson′s disease(PD).Methods Ninety-one cases of PD patients treated in the First Affiliated Hospital of Guangzhou Medical University from February 2017 to April 2018 were selected.According to the random number table method,the patients were divided into the observation group(46 cases)and the control group(45 cases).Patients in both groups were treated by conventional therapy such as back percussion and sputum suction,oxygen inhalation and atomization and nutritional support.The control group was given Levodopa and Benserazide Tablets,the observation group was given SNDBS treatment on the basis of the control group.After 3 months of treatment,the curative effect and adverse reactions of the two groups were compared.The unified Parkinson disease rating scale(UPDRS)score,quality of life score,uric acid(UA)and methane dicarboxylic aldehyde(MDA)level were compared between the two groups before and after 3 months of treatment.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the UPDRS score of the two groups were lower than those before treatment,and the observation group was lower than that of the control group;the quality of life score of the two groups were higher than those before treatment,and the observation group was higher than that of the control group,the differences were statistically significant(P<0.05);the UA and MDA level of the two groups were lower than those before treatment,and the observation group was lower than that of the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion SNDBS is effective in the adjunctive treatment of PD patients.It can improve the symptoms and quality of life of patients,and reduce oxidative stress level.
作者
杨应浩
姚谦明
程国雄
徐振球
谭红愉
YANG Yinghao;YAO Qianming;CHENG Guoxiong;XU Zhenqiu;TAN Hongyu(Department of Neurosurgery,the First Affiliated Hospital of Guangzhou Medical University,Guangdong Province,Guangzhou 510000,China;Department of Neurology,the First Affiliated Hospital of Guangzhou Medical University,Guangdong Province,Guangzhou 510000,China)
出处
《中国医药导报》
CAS
2019年第5期68-71,共4页
China Medical Herald
基金
广东省医学科研基金立项课题(A2013252)
关键词
丘脑底核
脑深部电刺激术
辅助治疗
帕金森病
临床效果
Subthalamic nucleus
Deep brain stimulation
Adjunctive treatment
Parkinson′s disease
Clinical effect
