摘要
微RNA(miRNA)是一组短链非编码RNA,通过调节特定信使RNA的靶标活性,在肿瘤、炎症等过程中发挥广泛作用。部分miRNA在消化系统肿瘤中的表达谱发生改变,有助于疾病的诊断和鉴别;差异表达的miRNA可能参与消化系统肿瘤的发生和发展,通过上调或下调下游靶基因、靶蛋白参与调控包括消化系统肿瘤在内的多种疾病;特异性miRNA表达谱也表明其可作为调节因子参与肿瘤增殖和分化。随着研究的不断深入,miRNA作为参与肿瘤调控的新型非侵入性生物标志物,对消化系统肿瘤早期诊断、预后评估和靶向治疗等方面的作用潜力巨大。
MicroRNAs(miRNAs) are a group of short-chain non-coding RNAs that play a wide-ranging role in tumors, inflammation,etc. by modulating specific messenger RNA target activities.The expression profile of some miRNAs in digestive system tumors is changed,which is helpful for the diagnosis and identification of diseases;differentially expressed miRNAs may be involved in the development and progression of digestive system tumors,which are involved in the regulation of various diseases including digestive system tumors by up-regulating or down-regulating downstream target genes and target proteins;specific miRNA expression profiles also indicate that they are involved in tumor proliferation and differentiation as regulatory factors.With the deepening of the research,miRNA as a novel non-invasive biomarker involved in tumor regulation has great potential for the early diagnosis,prognostic evaluation and targeted therapy of digestive system tumors.
作者
沙银中
刘雯
李亚东
彭红梅
刘旻
SHA Yingzhong;LIU Wen;LI Yadong;PENG Hongmei;LIU Min(Department of Clinical Laboratory,the First People′s Hospital of Kashgar,Kashi 844000,China;Department of Quality Management,the First People′s Hospital of Kashgar,Kashi 844000,China;Department of Reproductive Medicine,the First Affiliated Hospital of Shihezi University School of Medicine,Shihezi 832000,China)
出处
《医学综述》
2019年第4期681-686,共6页
Medical Recapitulate
关键词
消化系统恶性肿瘤
微RNA
胃癌
肝癌
食管癌
结直肠癌
Malignant tumors of digestive system
MicroRNA
Gastric cancer
Liver cancer
Esophageal carcinoma
Colorectal cancer
