摘要
碘是影响甲状腺功能的重要元素,妊娠期碘营养状况与甲状腺功能异常密切相关。亚临床性甲状腺功能减退症是常见的妊娠并发症,碘缺乏或碘过量均可引起亚临床性甲状腺功能减退症。碘缺乏可导致孕妇产生妊娠期高血压、流产、胎膜早破等不良妊娠结局,同时导致后代神经和认知缺陷等。早期补碘对治疗严重碘缺乏至关重要,但对轻中度碘缺乏的疗效仍存在争议。碘过量则会引起巨大儿、后代甲状腺功能紊乱等不良结果,故妊娠期筛查尿碘和指导合理补碘非常重要。
Iodine is an important element which can affect thyroid function.The iodine nutritional status during pregnancy is closely related to thyroid dysfunction.Subclinical hypothyroidism is a common pregnancy complication,and iodine deficiency or excess can cause subclinical hypothyroidism.Iodine deficiency can lead to adverse pregnancy outcomes such as pregnancy-induced hypertension,miscarriage,and premature rupture of membranes,as well as neurological and cognitive deficits in offsprings.Iodine supplementation in early time is essential for severe iodine deficiency therapy,but the efficacy of iodine supplementation for mild to moderate iodine deficiency remains controversial.Excessive iodine can cause adverse effects such as macrosomia and thyroid dysfunction in the offsprings.Therefore,it is very important to screen urine iodine and guide the reasonable supplementation of iodine during pregnancy.
作者
庄寒秋
许岚
蒋艳敏
徐湘
ZHUANG Hanqiu;XU Lan;JIANG Yanmin;XU Xiang(Department of Endocrinology,Affiliated Wuxi People′s Hospital of Nanjing Medical University,Wuxi 214023,China)
出处
《医学综述》
2019年第4期728-732,737,共6页
Medical Recapitulate
基金
无锡市科技局科技项目(CSE01011)
无锡市医院管理中心科研项目(YGZXL1322)
