摘要
目的系统评价温针灸联用玻璃酸钠治疗膝骨性关节炎的效果和安全性。方法检索PubMed、EMbase、Cochrane Library、CBM、WF、CNKI和VIP数据库建库至2018年7月21日关于温针灸联用玻璃酸钠治疗膝骨性关节炎的随机对照试验(RCT)和临床对照试验(CCT),并对全部纳入研究的参考文献进行追溯,由2个评价员根据纳入排除标准独立对纳入研究进行筛选和评价,然后进行数据提取。运用RevMan 5.3软件进行统计分析。结果共纳入20篇文献,共1719例患者,联合治疗组859例,玻璃酸钠组860例,经Meta分析表明:联合组对膝骨性关节炎疗效优于玻璃酸钠组(OR=4.45,95%CI:3.12～6.35,P <0.05)。各组均未发生不良反应。结论温针灸联用玻璃酸钠治疗膝骨性关节炎疗效显著,安全性较好。
Objective To systematically evaluate the curative effect and safety of warm acupuncture combined with Sodium Hyaluronate therapy in treatment of knee osteoarthritis. Methods The databases of PubMed, EMbase, Cochrane Library, CBM, WanFang, CNKI and VIP were retrieved for collecting randomized controlled trials (RCT) and clinic controlled trials (CCT) about warm acupuncture combined with Sodium Hyaluronate therapy in treatment of knee osteoarthritis from database building to July 21th, 2018, and reference lists enrolled were also searched. According to the inclusion and exclusion criteria, two reviewers screened and assessed the enrolled studies independently, and then the data was extracted. The data was given a Meta-analysis by using RevMan 5.3 software. Results A total of 20 studies were included, involving 1719 patients, with 859 cases in combination group and 860 cases in Sodium Hyaluronate group. The Meta-analysis showed: the clinical curative effect of the combination group in treating knee osteoarthritis was better than the Sodium Hyaluronate group (OR = 4.45, 95%CI: 3.12-6.35, P < 0.05). There were no adverse reactions in each group. Conclusion The combination treatment of warm acupuncture and Sodium Hyaluronate has significant curative effect, and the safety is good.
作者
姜慧晶
张树丹
JIANG Huijing;ZHANG Shudan(Department of Acupuncture and Moxibustion, Dalian Hospital of Traditional Chinese Medicine, Liaoning Province,Dalian 116013, China;Department of Pharmacy, Dalian Hospital of Traditional Chinese Medicine, Liaoning Province, Dalian 116013, China)
出处
《中国医药导报》
CAS
2019年第6期154-158,共5页
China Medical Herald
关键词
温针灸
玻璃酸钠
膝骨性关节炎
META分析
Warm acupuncture
Sodium Hyaluronate
Knee osteoarthritis
Meta-analysis
