摘要
目的探讨桃红四物汤类活血化瘀类中药对外伤患者凝血功能的影响。方法 120例脑外伤患者,采用随机数字表法分为观察组和对照组,各60例。对照组患者给予常规营养神经、改善微循环治疗,观察组患者在对照组基础上给予桃红四物汤类活血化瘀类汤方治疗。比较两组患者临床征象消失时间,治疗前及治疗后24 h、48 h、72 h、7 d凝血5项[血浆凝血酶原时间(PT)及活动度(ACT)、活化部分凝血酶原时间(APTT)、纤维蛋白原(Fbg)、凝血酶时间(TT)]、血小板计数、出血剩余量与总出血量比值。结果两组患者治疗前、治疗后24 h、48 h、72 h、7 d的PT、ACT、APTT、Fbg、TT、血小板计数比较差异均无统计学意义(P>0.05);观察组治疗后24 h、48 h、72 h、7 d血剩余量/总出血量比值均明显低于对照组,差异有统计学意义(P<0.05)。观察组患者头晕头痛消失时间(1.42±0.13)d、伤处疼痛消失时间(5.09±2.44)d、颅内积血吸收时间(8.63±3.16)d均明显短于对照组的(2.86±1.01)、(7.21±2.63)、(10.74±4.29)d,差异有统计学意义(P<0.05)。结论桃红四物汤类活血化瘀类中药汤方对外伤患者凝血功能影响不明显,但是能够明显缩短患者病程,促进脑积血的吸收。
Objective To discuss the effect of Huoxue Huayu Chinese medicine of Taohong Siwu decoction on blood coagulation function in traumatic patients. Methods A total of 120 brain trauma patients were divided by random number table into observation group and control group, with 60 cases in each group. The control group received conventional nutritional nerves and improved microcirculation therapy, and the observation group received Huoxue Huayu Chinese medicine of Taohong Siwu decoction on the basis of the control group. Comparison were made on disappearance time of clinical signs, 5 blood coagulation[ plasmin prothrombin time (PT) and activity (ACT), activated partial prothrombin time (APTT), fibrinogen (Fbg), thrombin time (TT)] before treatment and 24 h, 48 h, 72 h, 7 d after treatment, platelet count, residual bleeding/total bleeding between the two groups. Results Both groups had no statistically significant in PT, ACT, APTT, Fbg, TT and platelet count before treatment and 24 h, 48 h, 72 h, 7 d after treatment (P>0.05). The observation group had obviously lower residual bleeding/total bleeding 24 h, 48 h, 72 h, 7 d after treatment than the control group, and the difference was statistically significant (P<0.05). The observation group had obviously shorter dizziness and headache disappearance time as (1.42±0.13) d, wound pain disappearance time as (5.09±2.44) d and intracranial blood absorption time as (8.63±3.16) d, which were obviously shorter than (2.86±1.01),(7.21±2.63) and (10.74± 4.29) d in the control group, and their difference was statistically significant (P<0.05). Conclusion Huoxue Huayu Chinese medicine of Taohong Siwu decoction has no obvious effect on the coagulation function of patients with trauma, but it can significantly shorten the patient's course and promote the absorption of cerebral blood.
作者
蓝培桂
邓凤娟
麦辉
LAN Pei-gui;DENG Feng-juan;MAI Hui(Zhaoqing Gaoyao District Hospital of Traditional Chinese Medicine, Zhaoqing 526100, China)
出处
《中国现代药物应用》
2019年第5期151-153,共3页
Chinese Journal of Modern Drug Application
基金
探讨桃红四物汤类活血化瘀类中药汤方对外伤患者凝血功能的影响(项目编号:201804031112)
关键词
桃红四物汤
活血化瘀
外伤
凝血功能
Taohong Siwu decoction
Huoxue Huayu
Trauma
Blood coagulation function
