摘要
目的分析双重血浆置换(double filtration plasmapheresis,DFPP)对系统性红斑狼疮肺间质病变患者肺功能的影响。方法选取河南省人民医院2014年3月至2016年3月收治的系统性红斑狼疮肺间质病变患者50例为研究对象,按照随机数字表法分为试验组和对照组,每组25例。对照组患者给予强的松和环磷酰胺,试验组患者在对照组治疗基础上采用DFPP技术治疗。对两组患者免疫球蛋白水平、肺功能以及临床疗效进行评估。结果试验组有效率高于对照组,差异有统计学意义(P<0.05)。试验组治疗后血清IgA、IgG、IgM水平低于对照组,差异有统计学意义(P<0.05);试验组血清白蛋白浓度低于对照组,C3、C4水平均高于对照组,但差异均无统计学意义(P>0.05);两组患者治疗后ANA抗体、抗-dsDNA抗体转阴率比较,差异有统计学意义(P<0.05);试验组ANA抗体、抗-dsDNA抗体转阴率均高于对照组。治疗后试验组FVC,FEV1,PEV和PEF水平均高于对照组,差异有统计学意义(P<0.05)。结论 DFPP可有效改善系统性红斑狼疮肺间质病变患者肺功能,调节机体免疫功能,具有较高的临床应用价值。
Objective To study the effect of double filtration plasmapheresis(DFPP)on the pulmonary function in patients with systemic lupus erythematosus interstitial lung disease.Methods A total of 50 cases with systemic lupus erythematosus interstitial lung disease treated in Henan Provincial People's Hospital from March of 2014 to March of 2016 were selected as the research objects and divided into the experiment group and control group according the random number table,and each group consisted of 25 cases.The control group was treated with prednisone and cyclophosphamide,while the experiment group was treated with DFPP as well as prednisone and cyclophosphamide.The immunoglobulin level,pulmonary function and clinical curative effect were assessed in both groups.Results The effective rate of the experiment group was significantly higher than that of the control group(P<0.05).The levels of serum IgA,IgG and IgM after treatment was significantly lower in the experiment group than in the control group(P<0.05).The serum albumin concentration was lower and the levels of C3 and C4 were higher in the experiment group than in the control group,but there was no significant differences(P>0.05).The negative conversion rates of ANA and anti-dsDNA antibodies after treatment were statistically different between the two groups(P<0.05)and those in the experiment group were significantly higher than those in the control group(P<0.05).The levels of FVC,FEV1,PEV and PEF after treatment were significantly higher in the experiment group than in the control group(P<0.05).Conclusion DFPP can effectively improve the pulmonary function and regulate the immune function in patients with systemic lupus erythematosus interstitial lung disease,so it has high value of clinical application.
作者
夏璐
牛培元
陶琳
Xia Lu;Niu Peiyuan;Tao Lin(Department of Nephropathy,Rheumatology and Immunology,Henan Provincial People's Hospital,Zhengzhou 450003,China)
出处
《成都医学院学报》
CAS
2019年第1期44-47,共4页
Journal of Chengdu Medical College
基金
河南省科技攻关项目(No:152102310138)
关键词
DFPP联合糖皮质激素
系统性红斑狼疮
肺间质病变
肺功能
DFPP combined with glucocorticoids
Systemic lupus erythematosus
Interstitial lung disease
Pulmonary function
