摘要
肝活组织检查是肝纤维化诊断和分期的最敏感和特异的方法,但因其有创性及局限性,近年来肝纤维化无创评估方法在临床上得到广泛应用。其中瞬时弹性成像技术(TE)在病毒性肝炎、非酒精性脂肪性肝病、酒精性肝病、自身免疫性肝病等各种病因慢性肝病中的诊断效能已得到广泛验证,其对肝纤维化,尤其是肝硬化的诊断效能较好,已逐渐被写入一些国家临床指南。然而,TE对肝纤维化的诊断效能受相关因素,如转氨酶、胆红素、肝脏炎症、脂肪变性等影响。应结合具体的病因,联合多种无创方法,最大程度的提高诊断准确度。
Liver biopsy is the most sensitive and specific method for the diagnosis and staging of liver fibrosis, but its invasiveness and limitations have promoted the wide application of noninvasive evaluation methods for liver fibrosis in clinical practice in recent years. Various studies have proved the diagnostic efficiency of transient elastography (TE) in chronic liver diseases of various etiologies, such as viral hepatitis, nonalcoholic fatty liver disease, alcoholic liver disease, and autoimmune liver disease, especially in liver fibrosis and liver cirrhosis, and therefore, it has been incorporated into clinical practice guidelines in many countries. However, the diagnostic efficiency of TE in liver fibrosis is affected by several factors including aminotransferases, bilirubin, liver inflammation, and steatosis. Several noninvasive methods should be used in combination based on etiology to improve diagnostic accuracy.
作者
罗文萍
马红
王宇
LUO Wenping;MA Hong;WANG Yu(Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China)
出处
《临床肝胆病杂志》
CAS
北大核心
2019年第3期635-639,共5页
Journal of Clinical Hepatology
基金
国家科技重大专项(2017ZX10202202).
关键词
弹性成像技术
肝硬化
诊断
综述
elasticity imaging techniques
liver cirrhosis
diagnosis
review
