摘要
目的探究顺铂联合伊立替康以及依托泊苷对小细胞肺癌患者肺功能的影响及疗效分析。方法选取我院收治的150例小细胞肺癌患者作为研究对象,随机均分为观察组和对照组。观察组患者采用顺铂联合伊立替康和依托泊苷治疗,对照组患者采用顺铂联合伊立替康治疗。结果观察组患者的治疗有效率显著高于对照组(P<0.05),不良反应发生率明显低于对照组(P<0.05);治疗前,两组患者肿瘤组织中血管内皮生长因子(VEGF)、血小板-内皮细胞黏附分子(CD-31)以及低氧诱导因子(HIF-l)的蛋白表达水平比较,差异无统计学意义(P>0.05),治疗后均显著降低,且观察组显著低于对照组(P<0.05);治疗前,两组患者肺功能指标比较,差异无统计学意义(P>0.05),治疗后均有所改善,且观察组显著优于对照组(P<0.05)。结论顺铂联合伊立替康和依托泊苷治疗小细胞肺癌,可有效缓解病情,改善肺功能,降低不良反应。
Objective To explore the effect of cisplatin with irinotecan and etoposide on lung function of small cell lung cancer patients and to analyze the curative effect. Methods In this study, 150 patients with small cell lung cancer treated in our hospital were selected as the subjects. They were randomly divided into the observation group and the control group. Patients in the observation group were treated with cisplatin combined with irinotecan and etoposide, and those in the control group were treated with cisplatin combined with irinotecan. Results The treatment efficiency of the observation group was significantly higher than that of the control group (P<0.05). The incidence of postoperative adverse reactions was significantly lower in observation group than in the control group (P<0.05). Before treatment, there was no significant difference between the two groups (P>0.05). After treatment, the test results of tumor issues were significantly better in observation group than in control group (P<0.05). The two groups had no obvious differences in lung function index before treatment (P>0.05). But after treatment, both groups had the lung function indexes improved, and each index was better in observation group than in control group (P<0.05). Conclusion Cisplatin combined with irinotecan and etonoside can effectively alleviate the pain of patients with small cell lung cancer. This treatment can also improve the lung function of patients and reduce adverse reactions.
作者
周虹
吉顺莉
徐建华
陈先媛
ZHOU Hong;JI Shunli;XU Jianhua;CHEN Xianyuan(Pharmacy Department,Hai’an Affiliated Hospital of Nantong University,Nantong,Jiangsu,226600,China;Pharmacy Department,Affiliated Hospital of Nantong University,Nantong,Jiangsu,226601,China)
出处
《肿瘤药学》
CAS
2018年第6期885-888,共4页
Anti-Tumor Pharmacy
基金
国家自然科学基金资助项目(81201431)
关键词
小细胞肺癌
顺铂
伊立替康
依托泊苷
肺功能
Small cell lung cancer
Cisplatin
Irinotecan
Etoposide
Lung function
