摘要
目的探讨合并心房颤动(AF)的急性非ST段抬高型心肌梗死(NSTEMI)患者的血清半乳糖凝集素3和高敏C反应蛋白水平与预后的相关性。方法本研究为回顾性研究。纳入2014年1月至2015年12月在宝鸡市中医医院治疗的32例合并AF的NSTEMI患者作为AF组,并按年龄、性别匹配选取同期治疗的32例无AF的NSTEMI患者作为对照组,随访12个月,观察两组的主要心脑血管不良事件的情况。分析两组的血清半乳糖凝集素3和高敏C反应蛋白水平,应用多因素logistic回归分析评估血清半乳糖凝集素3和高敏C反应蛋白水平对预后的预测价值。结果与无AF的患者相比,合并AF患者的血清半乳糖凝集素3[(10.0±2.5)ng/ml比(8.6±2.5)ng/ml,P=0.02]和高敏C反应蛋白[(21.7±11.0)mg/L比(8.5±3.2)mg/L,P<0.001]明显升高。半乳糖凝集素3水平>7.53 ng/ml的患者发生不良事件的风险增加8倍(HR=8.06,95%CI:1.88～23.21,P=0.005),而高敏C反应蛋白>6.55 mg/L的患者发生不良事件的风险增加2.5倍(HR=2.53,95%CI:1.39～6.35,P=0.005)。结论合并AF的NSTEMI患者的血清半乳糖凝集素3和高敏C反应蛋白水平显著升高,半乳糖凝集素3和高敏C反应蛋白水平升高可预测患者发生心脑血管不良事件的风险。
Objective To investigate the correlation between serum galectin-3,hyper-sensitive C reactive protein(hs-CRP)levels and poor prognosis in patients with acute non-ST segment elevation acute myocardial infarction(NSTEMI)complicated with atrial fibrillation(AF).Methods This study was a retrospective study.Thirty-two patients with NSTEMI and AF were enrolled as the AF group,and another 32 cases of NSTEMI without AF as a control group,and all patients were followed-up to record the major adverse cardiac and cerebrovascular events(MACCE)for 12-month.The levels of serum galectin-3 and hsCRP between the two groups were compared,and the predictive value of serum galectin-3 and hsCRP for MACCE was analyzed by multivariate logistic regression analysis.Results Compared with patients without AF,the levels of serum galectin-3[(10.0±2.5)ng/ml vs.(8.6±2.5)ng/ml,P=0.02]and hsCRP[(21.7±11.0)mg/L vs.(8.5±3.2)mg/L,P<0.001]in patients with AF were significantly higher than those without AF.Patients with galectin-3>7.53 ng/ml had an 8-fold increased risk of MACCE(HR=8.06,95%CI:1.88-23.21,P=0.005)and those with hsCRP>6.55 mg/ml had a 2.5-fold increased risk of MACCE(HR=2.53,95%CI:1.39-6.35,P=0.005).Conclusions The levels of galectin-3 and hsCRP are significantly increased in NSTEMI patients with AF,and the elevated levels of galectin-3 and hsCRP could predict the risk of MACCE.
作者
邢尔克
贾军正
周红娟
Xing Erke;Jia Junzheng;Zhou Hongjuan(Department of Cardiology,Baoji City of Traditional Chinese Medicine,Baoji 721001,China;Department of Anesthesiology,Baoji City of Traditional Chinese Medicine,Baoji 721001,China)
出处
《中国心血管杂志》
2019年第1期62-66,共5页
Chinese Journal of Cardiovascular Medicine
关键词
心房颤动
心肌梗死
半乳糖凝集素3
高敏C反应蛋白
Atrial fibrillation
Myocardial infarction
Galectin-3
Hyper-sensitive C reactive protein
