摘要
目的探索磁共振T_2mapping和T_1mapping成像诊断兔进展期腰椎间盘退变的应用价值。方法 7只新西兰兔行椎间盘退变造模。造模前以及造模后1个月、3个月,行矢状位T_1WI、T_2WI、T_2mapping和T_1mapping扫描,基于T_2WI,对L_1～S_1的6个椎间盘行Pfirrmann分级,基于T_2mapping和T_1mapping测量椎间盘T_2值和T_1值。观察相应椎间盘病理改变,以病理结果非进展期和进展期退变为标准,使用接受者操作特征(ROC)曲线判断各成像指标的诊断效能。结果造模前、造模后1个月和造模后3个月,椎间盘T_2值显著降低(F=24.224, P <0.001),椎间盘T_1值无显著性差异(F=2.191, P=0.116)。诊断进展期椎间盘退变的效能从高到低依次为:T_2mapping+T_1mapping=T_2mapping> T_1mapping> Pfirrmann评分。结论 T_2mapping可以较准确地区分非进展期和进展期椎间盘退变。
Objective To apply magnetic resonance T2 mapping and T1 mapping in diagnosing progressive intervertebral disc degen-eration.Methods Seven New Zealand rabbits modeled with intervertebral disc degeneration underwent sagittal T1 WI, T2 WI, T2 mapping and T1 mapping before, and one and three months after modeling. Pfirrmann grade of six intervertebral discs(L1-S1) in each rabbit was obtained based on T2 WI and values of T2 and T1 based on T2 mapping and T1 map-ping. They were observed pathologically as progressive or non-progressive intervertebral disc degeneration. The diagnostic efficacy of these imaging markers was compared with receiver operating characteristic(ROC) curve according to pathological results.Results T2 values of intervertebral discs decreased after degeneration(F = 24.224, P < 0.001), while T1 values varied lit-tle(F = 2.191, P = 0.116). The diagnostic efficacy from more to less ranked as T2 mapping + T1 mapping = T2 mapping > T1 mapping > Pfirrmann grade.Conclusion T2 mapping may differentiate progressive intervertebral disc degeneration from non-progressive for clinic.
作者
胡莹莹
应金威
赵琪雯
王庆军
HU Ying-ying;YING Jin-wei;ZHAO Qi-wen;WANG Qing-jun(Department of radiology,navy general hospital,Beijing 100048;Department of Orthopedics,Naval General Hospital,Beijing 100048;Department of Pathology,Naval General Hospital,Beijing 100048)
出处
《中国康复理论与实践》
CSCD
北大核心
2019年第2期172-177,共6页
Chinese Journal of Rehabilitation Theory and Practice
关键词
椎间盘退变
磁共振成像
MAPPING
兔
intervertebral disc degeneration
magnetic resonance imaging
mapping
rabbits
