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脑卒中后继发性癫痫患者采用依达拉奉与丙戊酸钠联合治疗的临床效果及对NSE的影响分析 被引量:8

Clinical efficacy of edaravone combined with sodium valproate in treatment of epilepsy patients with previous stroks and nse influence analysis
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摘要 目的探讨采用依达拉奉与丙戊酸钠联合治疗脑卒中后继发性癫痫(Post Stroke Epilepsy,PSE)患者的临床效果及对血清神经元特异性烯醇化酶(Neuron Specific Enolase,NSE)的影响。方法选取2015年3月至2016年5月在本院住院治疗的70例PSE患者,随机分为观察组和对照组,每组有35例患者纳入,均给予降血压、降血脂、抗凝等常规治疗,对照组口服丙戊酸钠缓释片,观察组加依拉达奉静脉滴注,比较两组患者治疗效果与治疗前后NSE含量变化。结果经过1年随访,观察组治疗总有效率为94.29%,对照组治疗总有效率为77.14%,治疗后不同时期观察组NSE含量均明显低于对照组,以上各指标观察组均优于对照组,组间比较有统计学意义(P<0.05)。结论依达拉奉与丙戊酸钠联合治疗PSE可提高疗效,降低NSE水平,值得临床借鉴。 Objective Explore the clinical effect of edaravone combined with sodium valproate in the treatment of PSE and its influence on NSE. Methods 70 patients with PSE hospitalized in our hospital from March 2015 to May 2016 were randomly divided into observation group and control group, Each group had 35 cases. All patients were given antihypertensive, lipid-lowering and anticoagulant therapy. The control group was given valproate sustained-release tablets orally, while the observation group was given iradavone intravenously on this basis. Compare the curative effect of two groups of patients and Changes of NSE content before and after treatment. Results After one year follow-up, The total effective rate of the observation group was 94.29%, and that of the control group was 77.14%. The NSE content in the observation group was significantly lower than that the control group at different stages after treatment. The above indexes in the observation group were better than the control group, There was significant difference between groups (P<0.05). Conclusion Edaravone combined with sodium valproate in the treatment of PSE can improve the curative effect and reduce the level of NSE, It is worthy of clinical reference.
作者 范丽新 Fan Lixin(Department Of Neurology, Central People' s Hospital Of Xiuyan Manchu Autonomous County, Anshan, Liaoning, 114300, China)
出处 《当代医学》 2019年第3期104-105,共2页 Contemporary Medicine
关键词 脑卒中后继发性癫痫 依达拉奉 丙戊酸钠 神经元特异性烯醇化酶 影响 Secondary epilepsy after stroke Edaravone Sodium valproate NSE Affect
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  • 1朱秀丽,舒晓丹,丁晶,郭宁.老年癫痫患者脑电图检查与血清细胞因子水平及T淋巴细胞亚群的相关性[J].中国老年学杂志,2014,34(9):2372-2374. 被引量:23
  • 2全国神经外科癫痫防治协助组,周良辅,郑康,卢亦成,王硕,刘伟国,张祖勇,史继新,李昭杰,徐如祥,漆松涛,章翔,杨卫忠.神经外科围手术期和外伤后癫痫的预防及治疗指南(草案)[J].中华神经医学杂志,2006,5(12):1189-1190. 被引量:54
  • 3翁保慧.脑卒中后癫痫的临床特点[J].广西医学,2007,29(4):573-574. 被引量:7
  • 4De Herdt V, Dumont F, Henon H, et al.Early seizures in intracerebral hemorrhage:incidence,associated facaors,and outcome [J].Neurology, 2011,77(20) : 1794-1800.
  • 5Itoh T, Satou T, Nishida S, et al. Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats [J]. Neurechem Res, 2010,35 (2) : 348-355.
  • 6梁日标.临床分析卡马西平、托吡酯与丙戊酸钠治疗脑炎继发癫痫[J].医学信息,2013(22):247.
  • 7邵培宁,秦荣荣,尹彩霞. 针对性疗法治疗脑卒中后继发性癫痫的临床疗效[J]. 实用心脑肺血管病,2014,22(11):131-132.
  • 8Rieckmann K H,Campbell G H,Sax L J,et al.Clinical efficacy of topiramateor carbamazepine in treatment of partial seizures[J].Hainan medicine,2014,25(02):242-242.
  • 9Miller W R,Buelow J M,Bakas T.Older adults and new-onset epilepsy:elperiences with diagnosis[J].J Neu Iosci Nurs,2014,46(01):2-10.
  • 10周佑彬.丙戊酸钠应用于老年脑卒中后癫痫患者治疗的临床疗效分析[J].医学信息,2015,28(10):77-78.

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