摘要
目的探讨定经汤加味联合克罗米芬治疗肝郁肾虚型排卵障碍性不孕症患者的临床效果。方法选取2016年5月至2017年5月我院收治的肝郁肾虚型排卵障碍性不孕症患者80例作为研究对象,采用随机数字表法分为对照组与观察组,每组40例。对照组患者单纯给予克罗米芬治疗,观察组患者给予定经汤加味联合克罗米芬治疗。比较两组患者的治疗效果,检测比较两组患者的子宫内膜厚度、卵泡直径以及排卵和妊娠情况,检测比较两组患者的卵泡刺激素(FSH)、雌二醇(E2)及促黄体生成素(LH)水平。结果治疗3个疗程后,观察组患者的临床疗效显著优于对照组,差异有统计学意义(P <0. 05);观察组患者的子宫内膜厚度、卵泡直径及妊娠率均显著大(高)于对照组,差异有统计学意义(P <0. 05);两组患者的FSH、E2水平均显著提高,LH水平均显著降低,观察组患者的FSH、E2水平显著高于对照组,LH水平显著低于对照组,差异有统计学意义(P <0. 05)。结论定经汤加味联合克罗米芬治疗排卵障碍性肝郁肾虚型排卵障碍性不孕症患者,可有效地增加患者子宫内膜厚度,促进胚胎着床,提高妊娠率,改善患者内分泌和免疫调节功能,提高临床治疗效果。
Objective To investigate the clinical effect of modified Dingjing decoction combined with clomiphene for anovulatory infertility patients of liver stasis and kidney deficiency.Methods 80 cases of anovulatory infertility patients of liver stasis and kidney deficiency admitted to our hospital from May 2016 to May 2017 were selected and randomly divided into the control group and the observation group,with 40 cases in each group.The patients in the control group were treated with clomiphene alone and the patients in the observation group were treated with modified Dingjing decoction combined with clomiphene.The therapeutic effects of the two groups were compared.The endometrial thickness,follicular diameter,ovulation and pregnancy between the two groups were compared.Follicle stimulating hormone(FSH),estradiol(E2)and luteinizing hormone(LH)between the two groups were detected and compared.Results After 3 courses of treatment,the clinical efficacy of the observation group was significantly better than that in the control group,the difference was statistically significant(P<0.05).The endometrial thickness,follicular diameter and pregnancy rate of the observation group were significantly larger(higher)than those in the control group,the difference was statistically significant(P<0.05).The FSH and E2 levels in the two groups were significantly increased,and the LH level was significantly decreased.The FSH and E2 levels in the observation group were significantly higher than those in the control group,and the LH level was significantly lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Modified Dingjing decoction combined with clomiphene for anovulatory infertility patients of liver stasis and kidney deficiency can effectively increase the endometrial thickness,promote embryo implantation,improve the pregnancy rate,endocrine and immunomodulatory function,and clinical treatment effect.
作者
黄富娟
黄芳
张月桃
HUANG Fujuan;HUANG Fang;ZHANG Yuetao(Department of Traditional Chinese Medicine,the First People′s Hospital of Zhaoqing,Zhaoqing 526000,China;Department of Department of Obstetrics and Gynecology,the First People′s Hospital of Zhaoqing,Zhaoqing 526000,China)
出处
《内科》
2019年第1期30-32,50,共4页
Internal Medicine
基金
肇庆市科技创新计划项目(2016040304)
关键词
排卵障碍性不孕症
肝郁肾虚
加味定经汤
克罗米芬
Anovulatory infertility
Liver stasis and kidney deficiency
Modified Dingjing decoction
Clomiphene
