摘要
目的探讨复方苦参注射液联合卡培他滨和奥沙利铂方案(XELOX方案)对晚期结肠癌患者疗效及免疫功能的影响。方法将我院收治的78例晚期结肠癌患者随机分为实验组和对照组,各39例,对照组给予XELOX方案治疗,实验组加用复方苦参注射液,比较两组客观疗效、胃肠道不良反应及治疗前后免疫功能、卡氏(KPS)评分、癌胚抗原(CEA)的变化。结果实验组总有效率为84.62%,显著高于对照组的64.10%(P<0.05);两组治疗后KPS评分均明显升高(P<0.05),实验组升高幅度大于对照组(P <0. 05);两组治疗后CEA值均无明显变化,组间比较差异无统计学意义(P>0.05);治疗后,实验组CD4^+、CD8^+、CD4^+/CD8^+、NK细胞活性均明显升高(P <0.05),对照组CD4^+、CD4^+/CD8^+、NK细胞活性均明显降低(P <0. 05),组间比较差异均有统计学意义(P <0. 05);实验组胃肠道反应、骨髓抑制发生率显著低于对照组(P<0.05);两组肝功能异常发生率比较,差异无统计学意义(P>0.05)。结论复方苦参注射液联合XELOX方案对晚期结肠癌患者疗效较好,可提高免疫功能,减少胃肠道不良反应。
Objective To explore the effects of compound Kushen injection combined with xeloda and oxaliplatin(XELOX)regimen on the efficacy and immune function of patients with advanced colon cancer. Methods 78 cases of patients with advanced colon cancer admitted to our hospital were randomly divided into the experimental group and control group with 39 cases each.The control group was treated with XELOX regimen,and the experimental group was treated with compound Kushen injection combined with XELOX regimen.The objective efficacy,gastrointestinal adverse reactions,and immune function before and after the treatment,as well as Karnofsky performance score(KPS)and carcinoembryonic antigen(CEA)were compared between the two groups. Results The total effective rate in the experimental group was significantly higher than that in the control group(84.62% vs 64.10%)( P <0.05).The KPS score after the treatment in both groups were significantly increased( P <0.05),and the increase in the experimental group was greater than that in the control group( P < 0.05 ).There was no significant difference in CEA value between the two groups after the treatment( P >0.05).After the treatment,the CD4 +,CD8 +,CD4 +/CD8 +,and NK cell activity were significantly improved in the experimental group( P <0.05),while the CD4 +,CD4 +/CD8 +,and NK cell activity were significantly decreased in the control group( P <0.05),and there were significant differences between the two groups( P <0.05).The incidence rates of gastrointestinal reactions and myelosuppression in the experimental group were significantly lower than those in the control group( P < 0.05 ).There was no significant difference in the incidence rate of liver function abnormalities between the two groups( P >0.05). Conclusion Compound Kushen injection combined with XELOX regimen has a good efficacy for patients with advanced colon cancer,and it can improve immune function and reduce gastrointestinal adverse reactions.
作者
李程
应伟
LI Cheng;YING Wei(Department of Oncology,Guangan Hospital of West China,Sichuan University,Guangan 638000,China)
出处
《标记免疫分析与临床》
CAS
2019年第2期318-321,共4页
Labeled Immunoassays and Clinical Medicine
