摘要
脑出血具有高发病率和高死亡率的特点。近年研究表明,脑出血产生的继发性脑损伤机制主要涉及凝血酶诱导、红细胞裂解、毒性反应、氧化损伤和炎症反应等多个方面。根据不同的损伤机制,应运而生了多种脑出血的治疗策略,但是否能成功应用于临床还有待进一步研究。本文对脑出血后继发性损伤的潜在机制和新兴治疗方法进行了综述。
Intracerebral hemorrhage(ICH)has high mortality and morbidity.Recent studies have shown that the mechanism of secondary brain injury caused by ICH mainly involves the thrombin-induced injury,red blood cell lysis,toxic reaction,oxidative injury,inflammation and so on.According to different injury mechanism,several emerging therapeutic strategies for cerebral hemorrhage have developed.However,there are few therapies that can be successfully applied in clinic,which need to be further studied.This article mainly reviewed the potential mechanism and the emerging treatment methods of secondary brain injury after ICH.
作者
朱燕
朱东亚
ZHU Yan;ZHU Dong-Ya(School of Pharmacy,Nanjing Medical University,Nanjing 211166,China)
出处
《中国卒中杂志》
2019年第2期183-187,共5页
Chinese Journal of Stroke
基金
国家自然科学基金(81870912)作者单位211166南京南京医科大学药学院
关键词
脑出血
继发性脑损伤
损伤机制
治疗
Intracerebral hemorrhage
Secondary brain injury
Injury mechanism
Therapeutic method
