摘要
目的:探讨更昔洛韦联合神经节苷脂治疗病毒性脑炎的疗效及对患者血清和脑脊液指标的影响。方法:98例病毒性脑炎患者按照治疗先后分为单一用药组(n=49)和联合用药组(n=49),患者入院后均给予对症治疗,单一用药组同时给予5 mg/kg更昔洛韦+100 ml 5%葡萄糖溶液抗病毒治疗,联合用药组在单一用药组基础上加用40 mg神经节苷脂+250 ml5%葡萄糖溶液神经营养治疗,两组均用药14 d。观察治疗效果及临床症状体征的恢复时间,并分析治疗前、后两组血清相关指标(NSE、MBP、S100β蛋白)、脑脊液相关指标(蛋白定量、单核细胞数、总细胞数)水平。结果:联合用药组患者临床症状、体征恢复时间显著短于单一用药组(P<0.05),治疗有效率明显高于单一用药组(P<0.05);两组治疗后血清及脑脊液相关指标均获得明显改善(P<0.05),且联合用药组血清NSE、MBP、S100β蛋白水平均显著低于单一用药组血清(P<0.05),脑脊液中蛋白定量及总细胞数水平均显著低于单一用药组血清(P<0.05),两组均无明显不良反应发生。结论:病毒性脑炎患者给予对症治疗、抗病毒治疗的同时加用神经节苷脂对神经损伤给予针对性的治疗有利于患者的治疗和预后,安全可靠。
Objective: To investigate the efficacy of ganciclovir combined with gangliosides in the treatment of viral encephalitis and its impact on serum and cerebrospinal fluid indicators .Methods: According to the treatment,98 patients were divided into single medication group ( n =49) and combination medication group ( n =49). Patients were treated with symptomatic treatment after admission. The single drug group was given 5 mg/kg ganciclovir + 100 ml 5% glucose solution for antiviral treatment, The combination group was given neurotrophic therapy with 40 mg ganglioside + 250 ml 5% glucose solution on the basis of single drug group. Both groups were given 14 d. Observe the treatment effect and the recovery time of clinical symptoms and signs, analyze the serum related indexes (NSE, MBP, S100β protein) and cerebrospinal fluid related indexes (protein quantification, monocyte count, total cell number) before and after treatment.Results: The recovery time of clinical symptoms and signs in the combination group was significantly shorter than that in the single drug group ( P <0.05), and the treatment efficiency was significantly higher than that in the single drug group ( P <0.05). The serum and cerebrospinal fluid related indexes were significantly improved after treatment ( P <0.05), and the levels of serum NSE, MBP, and S100β protein in the combination group were significantly lower than those in the single drug group ( P <0.05). The protein quantification and total cell number in the cerebrospinal fluid were significantly lower than those in the single drug group ( P <0.05), no significant adverse reactions occurred in either group.Conclusion: In patients with viral encephalitis, symptomatic treatment and antiviral therapy combined with gangliosides for targeted treatment of nerve injury are beneficial to the treatment and prognosis of patients, safe and reliable, and worthy of clinical promotion.
作者
陈孔博
邵元
CHEN Kongbo;SHAO Yuan(Department of Internal Neurology, Central Hospital of Tongchuan Mining Bureau, Shaanxi Province Tongchuan 727000)
出处
《陕西医学杂志》
CAS
2019年第4期505-507,517,共4页
Shaanxi Medical Journal
基金
陕西省自然科学基金资助项目(2014JM4162)
关键词
病毒性脑炎
更昔洛韦
抗病毒治疗
神经节苷脂
营养神经
对比研究
Viral encephalitis
Ganciclovir
Antiviral treatment
Ganglioside
Nutritional nerve
Comparative study
