摘要
目的探讨抗结核药物联合胎盘多肽注射液治疗菌阳肺结核的临床疗效与痰涂片转阴率。方法选取2015年4月至2017年10月睢县中医院西医内科收治的136例菌阳肺结核患者为研究对象,按照随机数表法将其分为对照组(n=68)与观察组(n=68),两组患者全部采用抗结核药物治疗,另予以观察组胎盘多肽注射液。比较两组患者的痰涂片转阴率、用药不良反应与各项免疫功能指标。结果治疗第1个月后、第2个月后、第4个月后,观察组痰涂片转阴率均高于对照组,组间比较差异有统计学意义(P <0.05)。两组在转氨酶升高、消化道反应、药疹三方面的发生率差异无统计学意义(P> 0.05),但观察组复发率低于对照组(P <0.05)。治疗前,两组患者的CD3^+、CD4^+、CD8^+、CD4^+/CD8^+比较差异无统计学意义(P> 0.05);治疗后,观察组上述指标显著优于对照组(P <0.05)。结论在菌阳肺结核患者的临床治疗中,采用抗结核药物与胎盘多肽注射液联合治疗,拥有较高的痰涂片转阴率,效果较为理想,且不良反应较少,安全性高,值得临床应用。
Objective To investigate the clinical efficacy and sputum smear negative conversion rate of anti-tuberculosis drugs combined with placenta polypeptide injection in the treatment of bacterial positive pulmonary tuberculosis. Methods From April 2015 to October 2017, 136 patients with bacterial positive pulmonary tuberculosis admitted to the department of Western Medicine of Suixian Hospital of Traditional Chinese Medicine were selected as the research objects. They were divided into control group (n=68) and observation group (n=68) according to random number table method. All patients in the two groups were treated with anti-tuberculosis drugs, additionally, observation group was given placental polypeptide injection. The sputum smear negative conversion rate, adverse drug reactions and various immune function indexes of the two groups of patients were compared. Results After the first month, the second month and the fourth month of treatment, the sputum smear negative conversion rate in the observation group was higher than that in the control group, and the difference between the two groups was statistically significant (P < 0.05). There was no significant difference in the incidence of transaminase elevation, digestive tract reaction and drug eruption between the two groups (P > 0.05), but the recurrence rate in the observation group was lower than that in the control group (P < 0.05). Before treatment, there was no significant difference in CD3 +, CD4 +, CD8 +, CD4 +/CD8 + between the two groups (P > 0.05). After treatment, the above indexes in the observation group were significantly better than those in the control group (P < 0.05). Conclusion In the clinical treatment of patients with bacterial positive pulmonary tuberculosis, the combination of antituberculosis drugs and placental polypeptide injection has a higher sputum smear negative conversion rate, with ideal effect, less adverse reactions and high safety, which is worthy of clinical application.
作者
郭金仓
GUO Jin-cang(Department of Western Medicine, Suixian Hospital of Traditional Chinese Medicine, Shangqiu, Henan, 476900, China)
出处
《临床研究》
2019年第4期25-26,共2页
Clinical Research
关键词
菌阳肺结核
抗结核药物
胎盘多肽注射液
临床效果
痰涂片转阴率
bacillary tuberculosis
anti-tuberculosis drugs
placenta polypeptide injection
clinical effect
negativeconversion rate of sputum smear
