摘要
目的观察苦劳汤坐浴辅助内口虚挂线术治疗高位肛周脓肿患者临床疗效及对术后疼痛、血清激活素A(ACTA)和免疫功能的影响并探讨其作用机制。方法患者96例随机分为研究组与对照组各48例。两组均给予内口虚挂线术治疗,在此基础上对照组给予高锰酸钾坐浴治疗,研究组给予苦劳汤坐浴治疗。观察两组临床指标、临床疗效,检测ACTA、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)和免疫功能。结果研究组创面腐肉脱落时间、创面愈合时间均短于对照组,创面疼痛评分低于对照组(均P <0.05)。研究组总有效率为93.75%,高于对照组的77.08%(P <0.05)。治疗后两组ACTA、TNF-α、IL-6水平均低于治疗前(均P <0.05),且研究组各指标低于对照组(均P <0.05)。治疗后两组CD3+、CD4+、CD4+/CD8+水平均高于治疗前(均P <0.05),且研究组均高于对照组(均P <0.05);治疗后两组CD8+水平均低于治疗前(P <0.05),且研究组低于对照组(P <0.05)。结论苦劳汤坐浴辅助内口虚挂线术可有效减轻高位肛周脓肿患者疼痛程度,改善ACTA和免疫功能。
Objective: To observe the clinical effect and explore the mechanism of Kulao Decoction hip bath assisted with soft endostoma thread-drawing therapy on high perianal abscess and the effects of postoperative pain,serum activin A(ACTA) and immune function. Methods: 96 patients were divided into the study group and the control group according to the random number table,48 in each. Both groups were given soft endostoma thread-drawing treatment. On this basis,the control group was given potassium permanganate hip bath treatment,while the study group was given Kulao Decoction hip bath treatment. The clinical indices and clinical efficacy were observed,and the levels of ACTA,TNF-α,IL-6 and immune function were detected. Results: The carrion shedding time,wound healing time,wound pain degree of the study group were significantly lower than those of the control group(P < 0.05). The total effective rate of the study group was 93.75%,significantly higher than that of the control group 77.08%(P < 0.05). The levels of ACTA,TNF-α and IL-6 in the two groups after treatment were significantly lower than those before treatment(P < 0.05),and the study group was significantly lower than the control group(P < 0.05). The levels of CD3+,CD4+ and CD4+/CD8+ in two groups after treatment were significantly higher than those before treatment(P < 0.05),and the study group was significantly higher than control group(P < 0.05). The levels of CD8+ in two groups after treatment were significantly lower than those before treatment(P < 0.05),and the study group was significantly lower than the control group(P < 0.05). Conclusion: Kulao Decoction hip bath assisted with soft endostoma thread-drawing therapy can effectively relieve the pain degree of patients with perianal abscess,and improve the ACTA and immune function.
作者
刘冰
杨有名
赵建民
Liu Bing;Yang Youming;Zhao Jianmin(Rongjun Hospital of Qingzhou,Shandong,Qingzhou 262500,China)
出处
《中国中医急症》
2019年第3期432-434,441,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
山东省医药卫生科技发展计划项目(2015WS0143)
关键词
高位肛周脓肿
苦劳汤
高锰酸钾
内口虚挂线术
血清激活素A
High perianal abscess
Kulao Decoction
Potassium Permanganate
Soft endostoma thread-drawing internal virtual thread surgery
Serum activin A
