摘要
目的探讨简易负压引流对妇科手术伤口愈合及感染、术后瘢痕、血清IL-2、IL-8和IL-10的影响。方法选取2016年3月至2018年3月延安市人民医院诊治的120例行妇科手术患者作为研究对象,采用随机数字法将其分为观察组和对照组,每组60例患者。观察组患者术后给予自制简易负压引流装置引流;对照组患者术后给予传统方式引流。系统观察:①两组患者术后切口愈合情况;②两组患者术后切口发生感染情况;③两组患者术后瘢痕情况;④两组患者术后血清IL-2、IL-8、IL-10。结果①观察组患者甲级愈合率显著高于对照组患者,其差异具有统计学意义(χ~2=6.75,P<0.05);②观察组患者甲级愈合例数及比例与总有效率均显著高于对照组患者,其差异均具有统计学意义(χ~2=7.13,5.83,均P<0.05);③对照组患者发生感染19例,占比31.7%,其中浅表感染16例,占比26.7%,深部感染3例,占比5.0%,观察组发生感染4例,占比6.7%,全部为浅表感染,观察组术后发生感染情况显著低于对照组(χ~2=8.15,P<0.05);④两组患者术后4周,疤痕面积差异均无统计学(t=0.76,均P>0.05),术后8周、12周、16周,疤痕面积差异均有统计学,观察组显著小于对照组(t=4.37,5.62,7.49,均P<0.05);⑤术后1周,两组患者IL-2、IL-8和IL-10比较,差异均具有统计学意义(t=6.78,7.23,6.95,均P<0.05)。结论简易负压引流相对于传统切口引流,能够显著改善患者术后切口愈合情况,降低切口感染发生概率,减少术后瘢痕面积,调节术后炎症表达,装置简易,操作简单,值得临床应用和推广。
Objective To explore the effect of simple negative pressure drainage device on wound healing and infection, postoperative scar, serum IL-2, IL-8 and IL-10 in gynecologic surgery. Methods 120 patients with gynecological tumors treated in Yan'an People's Hospital from March 2016 to March 2018 were selected and divided into observation group (60 cases) and control group (60 cases). The control group received traditional drainage after operation. The observation group received self-made simple negative pressure drainage. Postoperative incision healing, postoperative incision infection, postoperative scar, serum IL-2, IL-8 and IL-10 in the two groups were observed. Results CD The grade A healing rate of observation group was significantly higher than that in control group, with statistically significant difference (X^2= 6. 75 , P < 0. 05 ).(2)In the observation group, the number and proportion of grade A healing and total effective rate were significantly higher than these in control group, with statistically significant differences (X^2=7. 13, 5. 83, P <0. 05).(3) In control group, there were 19 cases (31.1%) of infection, including 16 cases of superficial infection (26. 1%) and 3 cases of deep infection (5. 0%). In observation group, there were 4 cases of superficial infection (6.1%). The infection rate in observation group was significantly lower than that in control group (X^2 =8. 15 , P <0. 05).(4)There was no significant difference in scar area between the two groups at 4 weeks after operation (t = 0. 76, P > 0. 05 ). Differences in the scar area was statistically significant at 8 weeks, 12 weeks and 16 weeks after operation, and that of the observation group was significantly less than that of the control group (t = 4. 37, 5. 62, 7. 49 , all P < 0. 05 ).(5) At a week after operation, the differ-ences in IL-2, IL-8 and IL-10 between the two groups were statistically significant (t = 6. 78, 7. 23, 6. 95 , all P < 0.05). Conclusions Compared with the traditional negative pressure drainage, simple negative pressure drainage can significantly improve the postoperative wound healing, reduce the occurrence of wound infection, reduce postoperative scar area, expression and regulation of inflammation after operation, which is worthy of clinical application and popularization.
作者
张芬
毕雪玲
郭晓莉
朱伟艳
ZHANG Fen;BI Xueling;GUO Xiaoli;ZHU Weiyan(The First Ward Department of Obstetrics and Gynecology,Yan’an People's Hospital,Yan'an 716002,Shaanxi,China;Two Wards Department of Gynaecology,Qingyuan People's Hospital,Qingyuan 511518,Guangdong,China)
出处
《中国性科学》
2019年第3期82-85,共4页
Chinese Journal of Human Sexuality
基金
清远市社会发展领域自筹经费科技计划项目(2017B025)
关键词
简易负压引流
妇科手术
伤口愈合
感染
疤痕
Simple negative pressure drainage
Gynecologic operation
Wound healing
Infection
Scar
